CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prostamide/prostaglandin F synthase 
Protein Synonyms/Alias
 Prostamide/PG F synthase; Prostamide/PGF synthase; Protein FAM213B 
Gene Name
 FAM213B 
Gene Synonyms/Alias
 C1orf93 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
101DESKQLYKELGFKRYubiquitination[1, 2]
120ILPAALGKPVRDVAAubiquitination[1, 2]
130RDVAAKAKAVGIQGNubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). 
Sequence Annotation
 MOD_RES 108 108 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 198 AA 
Protein Sequence
MSTVDLARVG ACILKHAVTG EAVELRSLWR EHACVVAGLR RFGCVVCRWI AQDLSSLAGL 60
LDQHGVRLVG VGPEALGLQE FLDGDYFAGE LYLDESKQLY KELGFKRYNS LSILPAALGK 120
PVRDVAAKAK AVGIQGNLSG DLLQSGGLLV VSKGGDKVLL HFVQKSPGDY VPKEHILQVL 180
GISAEVCASD PPQCDREV 198 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome. 
Interpro
  
Pfam
  
SMART
  
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