UniProt Accession

 ADK_HUMAN; P55263; B7Z783; B7Z800; O00741; O00742; Q16710; Q5JQ11; Q9BTN2 

Genbank Protein ID

 U50196; U33936; U90338; U90339; AK301590; AK302706; AC012046; AC022026; AC022540; AC091699; AL357037; AL731576; CH471083; BC003568 

Genbank Nucleotide ID

 AAA97893.1; AAB01689.1; AAB50234.1; AAB50235.1; BAH13519.1; BAH13786.1; EAW54556.1; AAH03568.1 

Protein Name

 Adenosine kinase 

Protein Synonyms/Alias

 AK; Adenosine 5'-phosphotransferase 

Gene Name

 ADK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	VDKDFLDKYSLKPND	acetylation	[1]
47	VDKDFLDKYSLKPND	ubiquitination	[2]
51	FLDKYSLKPNDQILA	ubiquitination	[2]
71	ELFDELVKKFKVEYH	ubiquitination	[2]
117	DKFGEILKRKAAEAH	ubiquitination	[3, 4]
256	REQGFETKDIKEIAK	ubiquitination	[2, 4]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. 

Sequence Annotation

 ACT_SITE 317 317
 METAL 49 49 Magnesium 1.
 METAL 147 147 Magnesium 2.
 METAL 148 148 Magnesium 2.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 77 77 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004001; F:adenosine kinase activity; EXP:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0046085; P:adenosine metabolic process; IEA:Compara.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0032922; P:circadian regulation of gene expression; IEA:Compara.
 GO:0006175; P:dATP biosynthetic process; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
 GO:0043101; P:purine-containing compound salvage; TAS:Reactome.
 GO:0044342; P:type B pancreatic cell proliferation; IEA:Compara. 

Interpro

 IPR001805; Adenokinase.
 IPR002173; Carboh/pur_kinase_PfkB_CS.
 IPR011611; PfkB_dom. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 

PRINTS

 PR00989; ADENOKINASE.