CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine synthetase 
Protein Synonyms/Alias
  
Gene Name
 PfSAMS 
Gene Synonyms/Alias
 PFI1090w 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
81KVTRDVLKHIGYDDEacetylation[1]
182TQITIEYKNKGSCGGacetylation[1]
210TQHAEDIKYEQLKTDacetylation[1]
230IKYVIPEKLLDNETLacetylation[1]
305AKSLVANKFCRRVLVacetylation[1]
371LTEPVFSKTSAYGHFacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
 Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Potassium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MSQLKIKRGN FLFTSESVNE GHPDKICDQI SDAILDSCLR EDPYSKVACE VCAKKNYIFI 60
FGEITTKAKV NYDKVTRDVL KHIGYDDESK GLDYKTAEIK VSIDEQSPDI AQCVHENRSP 120
ELIGAGDQGI MFGYATDETE NYMPLTHHYA TLLGKRLTEV RKLGILPYLG PDGKTQITIE 180
YKNKGSCGGH LEPLRVHTVL ISTQHAEDIK YEQLKTDLME NVIKYVIPEK LLDNETLYYL 240
NPSGKFVLGG PAADAGLTGR KIICDTYGGW GAHGGGAFSG KDASKVDRSA AYYLRFIAKS 300
LVANKFCRRV LVQASYSIGI ANPISLNVNS YGTVSTGYTD YDLEQIILRN FDLRPGFIIQ 360
ELKLTEPVFS KTSAYGHFGR EGDTFTWEKI KDLSHEKNAL KN 402 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR022631; ADOMET_SYNTHASE_CS.
 IPR022630; S-AdoMet_synt_C.
 IPR022629; S-AdoMet_synt_central.
 IPR022628; S-AdoMet_synt_N.
 IPR002133; S-AdoMet_synthetase.
 IPR022636; S-AdoMet_synthetase_sfam. 
Pfam
 PF02773; S-AdoMet_synt_C
 PF02772; S-AdoMet_synt_M
 PF00438; S-AdoMet_synt_N 
SMART
  
PROSITE
 PS00376; ADOMET_SYNTHASE_1
 PS00377; ADOMET_SYNTHASE_2 
PRINTS