CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubulin-specific chaperone C 
Protein Synonyms/Alias
 Tubulin-folding cofactor C; CFC 
Gene Name
 TBCC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151KDAASSTKVDAAPGIubiquitination[1]
173QDSPLPKKAEGDLGPubiquitination[1]
196LESQVLEKRASELHQubiquitination[1]
312SSGLDRSKNNWNDVDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Tubulin-folding protein; involved in the final step of the tubulin folding pathway. 
Sequence Annotation
 DOMAIN 171 323 C-CAP/cofactor C-like.
 MOD_RES 168 168 Phosphoserine.  
Keyword
 3D-structure; Chaperone; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MESVSCSAAA VRTGDMESQR DLSLVPERLQ RREQERQLEV ERRKQKRQNQ EVEKENSHFF 60
VATFVRERAA VEELLERAES VERLEEAASR LQGLQKLIND SVFFLAAYDL RQGQEALARL 120
QAALAERRRG LQPKKRFAFK TRGKDAASST KVDAAPGIPP AVESIQDSPL PKKAEGDLGP 180
SWVCGFSNLE SQVLEKRASE LHQRDVLLTE LSNCTVRLYG NPNTLRLTKA HSCKLLCGPV 240
STSVFLEDCS DCVLAVACQQ LRIHSTKDTR IFLQVTSRAI VEDCSGIQFA PYTWSYPEID 300
KDFESSGLDR SKNNWNDVDD FNWLARDMAS PNWSILPEEE RNIQWD 346 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005874; C:microtubule; TAS:ProtInc.
 GO:0032391; C:photoreceptor connecting cilium; IDA:UniProtKB.
 GO:0051087; F:chaperone binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome.
 GO:0000902; P:cell morphogenesis; IEA:InterPro.
 GO:0007023; P:post-chaperonin tubulin folding pathway; IDA:UniProtKB. 
Interpro
 IPR017901; C-CAP_CF_C-like.
 IPR016098; CAP/MinC_C.
 IPR006599; CARP_motif.
 IPR012945; Tubulin-bd_cofactor_C. 
Pfam
 PF07986; TBCC 
SMART
 SM00673; CARP 
PROSITE
 PS51329; C_CAP_COFACTOR_C 
PRINTS