CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011988
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-CoA carboxylase 1 
Protein Synonyms/Alias
 ACC1; ACC-alpha; Biotin carboxylase 
Gene Name
 ACACA 
Gene Synonyms/Alias
 ACAC; ACC1; ACCA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
218WQENDFSKRILNVPQubiquitination[1]
230VPQELYEKGYVKDVDubiquitination[1]
1730KITDIIGKEEGIGPEubiquitination[1]
1858SVPLLNSKDPIDRIIubiquitination[1]
1871IIEFVPTKTPYDPRWubiquitination[1]
2235SVIEENIKCISRDYVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. 
Sequence Annotation
 DOMAIN 117 618 Biotin carboxylation.
 DOMAIN 275 466 ATP-grasp.
 DOMAIN 752 818 Biotinyl-binding.
 DOMAIN 1698 2194 Carboxyltransferase.
 NP_BIND 315 320 ATP (Potential).
 ACT_SITE 441 441 By similarity.
 METAL 424 424 Manganese 1 (By similarity).
 METAL 437 437 Manganese 1 (By similarity).
 METAL 437 437 Manganese 2 (By similarity).
 METAL 439 439 Manganese 2 (By similarity).
 BINDING 1823 1823 Coenzyme A (By similarity).
 BINDING 2127 2127 Coenzyme A (By similarity).
 BINDING 2129 2129 Coenzyme A (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 53 53 Phosphoserine.
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 488 488 Phosphoserine.
 MOD_RES 786 786 N6-biotinyllysine (By similarity).
 MOD_RES 1201 1201 Phosphoserine (By similarity).
 MOD_RES 1216 1216 Phosphoserine (By similarity).
 MOD_RES 1263 1263 Phosphoserine.
 MOD_RES 1334 1334 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Allosteric enzyme; Alternative promoter usage; ATP-binding; Biotin; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Ligase; Lipid biosynthesis; Lipid metabolism; Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2346 AA 
Protein Sequence
MEGSPEENKE MRYYMLQRSS MSGLHLVKQG RDRKKIDSQR DFTVASPAEF VTRFGGNKVI 60
EKVLIANNGI AAVKCMRSIR RWSYEMFRNE RAIRFVVMVT PEDLKANAEY IKMADHYVPV 120
PGGPNNNNYA NVELILDIAK RIPVQAVWAG WGHASENPKL PELLLKNGIA FMGPPSQAMW 180
ALGDKIASSI VAQTAGIPTL PWSGSGLRVD WQENDFSKRI LNVPQELYEK GYVKDVDDGL 240
QAAEEVGYPV MIKASEGGGG KGIRKVNNAD DFPNLFRQVQ AEVPGSPIFV MRLAKQSRHL 300
EVQILADQYG NAISLFGRDC SVQRRHQKII EEAPATIATP AVFEHMEQCA VKLAKMVGYV 360
SAGTVEYLYS QDGSFYFLEL NPRLQVEHPC TEMVADVNLP AAQLQIAMGI PLYRIKDIRM 420
MYGVSPWGDS PIDFEDSAHV PCPRGHVIAA RITSENPDEG FKPSSGTVQE LNFRSNKNVW 480
GYFSVAAAGG LHEFADSQFG HCFSWGENRE EAISNMVVAL KELSIRGDFR TTVEYLIKLL 540
ETESFQMNRI DTGWLDRLIA EKVQAERPDT MLGVVCGALH VADVSLRNSV SNFLHSLERG 600
QVLPAHTLLN TVDVELIYEG VKYVLKVTRQ SPNSYVVIMN GSCVEVDVHR LSDGGLLLSY 660
DGSSYTTYMK EEVDRYRITI GNKTCVFEKE NDPSVMRSPS AGKLIQYIVE DGGHVFAGQC 720
YAEIEVMKMV MTLTAVESGC IHYVKRPGAA LDPGCVLAKM QLDNPSKVQQ AELHTGSLPR 780
IQSTALRGEK LHRVFHYVLD NLVNVMNGYC LPDPFFSSKV KDWVERLMKT LRDPSLPLLE 840
LQDIMTSVSG RIPPNVEKSI KKEMAQYASN ITSVLCQFPS QQIANILDSH AATLNRKSER 900
EVFFMNTQSI VQLVQRYRSG IRGHMKAVVM DLLRQYLRVE TQFQNGHYDK CVFALREENK 960
SDMNTVLNYI FSHAQVTKKN LLVTMLIDQL CGRDPTLTDE LLNILTELTQ LSKTTNAKVA 1020
LRARQVLIAS HLPSYELRHN QVESIFLSAI DMYGHQFCIE NLQKLILSET SIFDVLPNFF 1080
YHSNQVVRMA ALEVYVRRAY IAYELNSVQH RQLKDNTCVV EFQFMLPTSH PNRGNIPTLN 1140
RMSFSSNLNH YGMTHVASVS DVLLDNSFTP PCQRMGGMVS FRTFEDFVRI FDEVMGCFSD 1200
SPPQSPTFPE AGHTSLYDED KVPRDEPIHI LNVAIKTDCD IEDDRLAAMF REFTQQNKAT 1260
LVDHGIRRLT FLVAQKDFRK QVNYEVDRRF HREFPKFFTF RARDKFEEDR IYRHLEPALA 1320
FQLELNRMRN FDLTAIPCAN HKMHLYLGAA KVEVGTEVTD YRFFVRAIIR HSDLVTKEAS 1380
FEYLQNEGER LLLEAMDELE VAFNNTNVRT DCNHIFLNFV PTVIMDPSKI EESVRSMVMR 1440
YGSRLWKLRV LQAELKINIR LTPTGKAIPI RLFLTNESGY YLDISLYKEV TDSRTAQIMF 1500
QAYGDKQGPL HGMLINTPYV TKDLLQSKRF QAQSLGTTYI YDIPEMFRQS LIKLWESMST 1560
QAFLPSPPLP SDMLTYTELV LDDQGQLVHM NRLPGGNEIG MVAWKMTFKS PEYPEGRDII 1620
VIGNDITYRI GSFGPQEDLL FLRASELARA EGIPRIYVSA NSGARIGLAE EIRHMFHVAW 1680
VDPEDPYKGY RYLYLTPQDY KRVSALNSVH CEHVEDEGES RYKITDIIGK EEGIGPENLR 1740
GSGMIAGESS LAYNEIITIS LVTCRAIGIG AYLVRLGQRT IQVENSHLIL TGAGALNKVL 1800
GREVYTSNNQ LGGIQIMHNN GVTHCTVCDD FEGVFTVLHW LSYMPKSVHS SVPLLNSKDP 1860
IDRIIEFVPT KTPYDPRWML AGRPHPTQKG QWLSGFFDYG SFSEIMQPWA QTVVVGRARL 1920
GGIPVGVVAV ETRTVELSIP ADPANLDSEA KIIQQAGQVW FPDSAFKTYQ AIKDFNREGL 1980
PLMVFANWRG FSGGMKDMYD QVLKFGAYIV DGLRECCQPV LVYIPPQAEL RGGSWVVIDS 2040
SINPRHMEMY ADRESRGSVL EPEGTVEIKF RRKDLVKTMR RVDPVYIHLA ERLGTPELST 2100
AERKELENKL KEREEFLIPI YHQVAVQFAD LHDTPGRMQE KGVISDILDW KTSRTFFYWR 2160
LRRLLLEDLV KKKIHNANPE LTDGQIQAML RRWFVEVEGT VKAYVWDNNK DLAEWLEKQL 2220
TEEDGVHSVI EENIKCISRD YVLKQIRSLV QANPEVAMDS IIHMTQHISP TQRAEVIRIL 2280
STMDSPST 2288 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003989; F:acetyl-CoA carboxylase activity; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004075; F:biotin carboxylase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006084; P:acetyl-CoA metabolic process; ISS:UniProtKB.
 GO:0006853; P:carnitine shuttle; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0006633; P:fatty acid biosynthetic process; ISS:UniProtKB.
 GO:0055088; P:lipid homeostasis; IEA:Compara.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0044268; P:multicellular organismal protein metabolic process; IEA:Compara.
 GO:0031325; P:positive regulation of cellular metabolic process; TAS:Reactome.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
 GO:0001894; P:tissue homeostasis; IEA:Compara.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 
Interpro
 IPR013537; AcCoA_COase_cen.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR001882; Biotin_BS.
 IPR011764; Biotin_carboxylation_dom.
 IPR005482; Biotin_COase_C.
 IPR000089; Biotin_lipoyl.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR000022; Carboxyl_trans.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N.
 IPR016185; PreATP-grasp_dom.
 IPR011054; Rudment_hybrid_motif.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF08326; ACC_central
 PF02785; Biotin_carb_C
 PF00364; Biotin_lipoyl
 PF01039; Carboxyl_trans
 PF00289; CPSase_L_chain
 PF02786; CPSase_L_D2 
SMART
 SM00878; Biotin_carb_C 
PROSITE
 PS50975; ATP_GRASP
 PS50979; BC
 PS00188; BIOTIN
 PS50968; BIOTINYL_LIPOYL
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER
 PS00866; CPSASE_1
 PS00867; CPSASE_2 
PRINTS