UniProt Accession

 FIBB_HUMAN; P02675; B2R7G3; Q3KPF2 

Genbank Protein ID

 J00129; J00131; J00130; J00132; J00133; M64983; AF388026; AK312972; CH471056; BC106760; AH002694; X05018 

Genbank Nucleotide ID

 AAA52429.1; AAA98115.1; AAA98115.1; AAA98116.1; AAA18024.2; AAK62470.1; BAG35810.1; EAX04932.1; AAI06761.1; AAA52445.1; CAA28674.1 

Protein Name

 Fibrinogen beta chain 

Protein Synonyms/Alias

 Fibrinopeptide B; Fibrinogen beta chain 

Gene Name

 FGB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
264	IQPDSSVKPYRVYCD	acetylation	[1]
295	GSVDFGRKWDPYKQG	glycation	[2]
353	DWKGDKVKAHYGGFT	glycation	[2]

Reference

 [1] Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: a mass spectrometric and isotope labeling study.
 Svensson J, Bergman AC, Adamson U, Blombäck M, Wallén H, Jörneskog G.
 Biochem Biophys Res Commun. 2012 May 4;421(2):335-42. [PMID: 22507986]
 [2] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. 

Sequence Annotation

 DOMAIN 232 488 Fibrinogen C-terminal.
 REGION 45 47 Beta-chain polymerization, binding distal
 MOD_RES 31 31 Pyrrolidone carboxylic acid.
 CARBOHYD 394 394 N-linked (GlcNAc...).
 DISULFID 95 95 Interchain (with C-55 in alpha chain).
 DISULFID 106 106 Interchain (with C-68 in alpha chain).
 DISULFID 110 110 Interchain (with C-45 in gamma chain).
 DISULFID 223 223 Interchain (with C-184 in alpha chain).
 DISULFID 227 227 Interchain (with C-161 in gamma chain).
 DISULFID 231 316
 DISULFID 241 270
 DISULFID 424 437  

Keyword

 3D-structure; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0072562; C:blood microparticle; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0005577; C:fibrinogen complex; TAS:ProtInc.
 GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 

Pfam

 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 

SMART

 SM00186; FBG 

PROSITE

 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 

PRINTS