| Tag | Content |
|---|
| CPLM ID | CPLM-000111 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribonuclease T2 |
Protein Synonyms/Alias | Ribonuclease 6 |
Gene Name | RNASET2 |
Gene Synonyms/Alias | RNASE6PL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 157 | VLLKLGIKPSINYYQ | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. |
Sequence Annotation | ACT_SITE 65 65 By similarity.
ACT_SITE 114 114 By similarity.
ACT_SITE 118 118 By similarity.
CARBOHYD 76 76 N-linked (GlcNAc...).
CARBOHYD 106 106 N-linked (GlcNAc...).
CARBOHYD 212 212 N-linked (GlcNAc...).
DISULFID 48 55
DISULFID 75 121
DISULFID 184 241
DISULFID 202 213 |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Endonuclease; Endoplasmic reticulum; Glycoprotein; Hydrolase; Lysosome; Nuclease; Polymorphism; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 256 AA |
Protein Sequence | MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK IQNDCRDPPD 60
YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV IHSFPNRSRF WKHEWEKHGT 120
CAAQVDALNS QKKYFGRSLE LYRELDLNSV LLKLGIKPSI NYYQVADFKD ALARVYGVIP 180
KIQCLPPSQD EEVQTIGQIE LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV 240
CEDGPVFYPP PKKTKH 256 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |