CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal protein S6 modification protein 
Protein Synonyms/Alias
  
Gene Name
 rimK 
Gene Synonyms/Alias
 b0852; JW0836 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
272PGLEGIEKTTGIDIAacetylation[1]
281TGIDIAGKMIRWIERacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6. 
Sequence Annotation
 DOMAIN 104 287 ATP-grasp.
 NP_BIND 177 187 ATP (By similarity).
 METAL 248 248 Magnesium or manganese 1 (By similarity).
 METAL 260 260 Magnesium or manganese 1 (By similarity).
 METAL 260 260 Magnesium or manganese 2 (By similarity).
 METAL 262 262 Magnesium or manganese 2 (By similarity).
 BINDING 141 141 ATP (By similarity).
 BINDING 203 203 ATP (By similarity).  
Keyword
 3D-structure; ATP-binding; Complete proteome; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 300 AA 
Protein Sequence
MKIAILSRDG TLYSCKRLRE AAIQRGHLVE ILDPLSCYMN INPAASSIHY KGRKLPHFDA 60
VIPRIGTAIT FYGTAALRQF EMLGSYPLNE SVAIARARDK LRSMQLLARQ GIDLPVTGIA 120
HSPDDTSDLI DMVGGAPLVV KLVEGTQGIG VVLAETRQAA ESVIDAFRGL NAHILVQEYI 180
KEAQGCDIRC LVVGDEVVAA IERRAKEGDF RSNLHRGGAA SVASITPQER EIAIKAARTM 240
ALDVAGVDIL RANRGPLVME VNASPGLEGI EKTTGIDIAG KMIRWIERHA TTEYCLKTGG 300 
Gene Ontology
 GO:0016881; F:acid-amino acid ligase activity; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0030145; F:manganese ion binding; IEA:HAMAP.
 GO:0018410; P:C-terminal protein amino acid modification; IMP:EcoCyc.
 GO:0006412; P:translation; IEA:HAMAP. 
Interpro
 IPR011761; ATP-grasp.
 IPR013651; ATP-grasp_RimK-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR023533; Ribosomal_S6_modifier_RimK.
 IPR004666; RpS6_RimK/Lys_biosynth_LsyX. 
Pfam
 PF08443; RimK 
SMART
  
PROSITE
 PS50975; ATP_GRASP 
PRINTS