UniProt Accession

 PTMA_RAT; P06302; Q569C8 

Genbank Protein ID

 M20035; M86564; M33024; X55326; BC061972; BC092569 

Genbank Nucleotide ID

 AAA42241.1; AAA40758.1; AAA41931.1; CAA39028.1; AAH61972.1; AAH92569.1 

Protein Name

 Prothymosin alpha 

Protein Synonyms/Alias

 Prothymosin alpha, N-terminally processed; Thymosin alpha 

Gene Name

 Ptma 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	TSSEITTKDLKEKKE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylserine; in Prothymosin alpha, N-
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 8 8 Phosphothreonine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphothreonine (By similarity).
 MOD_RES 14 14 Phosphothreonine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 102 102 Phosphothreonine (By similarity).
 MOD_RES 108 108 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 112 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030154; P:cell differentiation; TAS:RGD.
 GO:0008283; P:cell proliferation; TAS:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:RGD. 

Interpro

 IPR004931; Pro/parathymosin. 

Pfam

 PF03247; Prothymosin 

SMART

  

PROSITE

  

PRINTS