UniProt Accession

 PYRC_YEAST; P20051; D6VZ56 

Genbank Protein ID

 X07561; U20162; U20939; BK006945 

Genbank Nucleotide ID

 CAA30444.1; AAB67491.1; AAB67510.1; DAA09722.1 

Protein Name

 Dihydroorotase 

Protein Synonyms/Alias

 DHOase 

Gene Name

 URA4 

Gene Synonyms/Alias

 YLR420W; L9931.1 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
195	KTIEDINKNVKKATD	acetylation	[1]
250	VKAAVSGKPYFFFGS	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 METAL 14 14 Zinc 1 (By similarity).
 METAL 16 16 Zinc 1 (By similarity).
 METAL 98 98 Zinc 1; via carbamate group (By
 METAL 98 98 Zinc 2; via carbamate group (By
 METAL 137 137 Zinc 2 (By similarity).
 METAL 180 180 Zinc 2 (By similarity).
 METAL 258 258 Zinc 1 (By similarity).
 MOD_RES 98 98 N6-carboxylysine (By similarity).  

Keyword

 Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004151; F:dihydroorotase activity; IMP:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IMP:SGD.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006221; P:pyrimidine nucleotide biosynthetic process; IMP:SGD. 

Interpro

 IPR004721; DHOdimr.
 IPR002195; Dihydroorotase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00482; DIHYDROOROTASE_1
 PS00483; DIHYDROOROTASE_2 

PRINTS