UniProt Accession

 GSTA4_MOUSE; P24472; Q9CQ81; Q9CTY7; Q9CY87; Q9D038 

Genbank Protein ID

 L06047; AK008189; AK008193; AK008400; AK008490; AK009668; AK010098; AK011177; AK011841; AK019100; AK019271; BC012639 

Genbank Nucleotide ID

 AAA37754.1; BAB25520.1; BAB25524.1; BAB25649.1; BAB25696.1; BAB26429.1; BAB26701.1; BAB27449.1; BAB27873.1; BAB31546.1; BAB31640.1; AAH12639.1 

Protein Name

 Glutathione S-transferase A4 

Protein Synonyms/Alias

 GST A4-4; GSTA4-4; GST class-alpha member 4; Glutathione S-transferase 5.7; GST 5.7 

Gene Name

 Gsta4 

Gene Synonyms/Alias

 Gsta 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MAAKPKLYYFNGR	ubiquitination	[1]
196	SNIPTIKKFLQPGSQ	acetylation	[2]
196	SNIPTIKKFLQPGSQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 208 GST C-terminal.
 REGION 54 55 Glutathione binding.
 REGION 67 68 Glutathione binding.
 BINDING 9 9 Glutathione (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004364; F:glutathione transferase activity; ISS:UniProtKB.
 GO:0006749; P:glutathione metabolic process; ISS:UniProtKB. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01266; GSTRNSFRASEA.