CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Butyrophilin subfamily 3 member A1 
Protein Synonyms/Alias
 CD277 
Gene Name
 BTN3A1 
Gene Synonyms/Alias
 BTF5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83VNVYADGKEVEDRQSubiquitination[1]
108RDGITAGKAALRIHNubiquitination[1]
123VTASDSGKYLCYFQDubiquitination[1]
299EMAWSTMKQEQSTRVubiquitination[1]
334SAYNEWKKALFKPADubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. 
Sequence Annotation
 DOMAIN 30 139 Ig-like V-type 1.
 DOMAIN 145 236 Ig-like V-type 2.
 DOMAIN 322 513 B30.2/SPRY.
 CARBOHYD 115 115 N-linked (GlcNAc...).
 DISULFID 52 126
 DISULFID 166 220  
Keyword
 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 60
ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 120
SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS 180
NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP 240
FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ 300
EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPA DVILDPKTAN PILLVSEDQR 360
SVQRAKEPQD LPDNPERFNW HYCVLGCESF ISGRHYWEVE VGDRKEWHIG VCSKNVQRKG 420
WVKMTPENGF WTMGLTDGNK YRTLTEPRTN LKLPKPPKKV GVFLDYETGD ISFYNAVDGS 480
HIHTFLDVSF SEALYPVFRI LTLEPTALTI CPA 513 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0050798; P:activated T cell proliferation; IMP:UniProtKB.
 GO:0072643; P:interferon-gamma secretion; IMP:UniProtKB.
 GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR013162; CD80_C2-set.
 IPR008985; ConA-like_lec_gl_sf.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR006574; PRY.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08205; C2-set_2
 PF00622; SPRY
 PF07686; V-set 
SMART
 SM00409; IG
 SM00589; PRY
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50835; IG_LIKE 
PRINTS
 PR01407; BUTYPHLNCDUF.