CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009147
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 10A 
Protein Synonyms/Alias
 EBP50-PDX interactor of 64 kDa; EPI64 protein 
Gene Name
 Tbc1d10a 
Gene Synonyms/Alias
 Epi64; Tbc1d10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
137KLQQNPGKFDELDMSubiquitination[1, 2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Acts as GTPase-activating protein for RAB27A (By similarity). 
Sequence Annotation
 DOMAIN 111 299 Rab-GAP TBC.
 REGION 497 500 Binding to the PDZ domain of EBP50 (By
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 407 407 Phosphoserine.  
Keyword
 Cell projection; Complete proteome; GTPase activation; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MAKSSRENGP REPAAGGSLS GTRESLAQGP DAATADELSS LGSDSEANGF AERRIDKFGF 60
IVGSQGAEGA LEEVPLEVLR QRESKWLDML NNWDKWMAKK HKKIRLRCQK GIPPSLRGRA 120
WQYLSGGKVK LQQNPGKFDE LDMSPGDPKW LDVIERDLHR QFPFHEMFVS RGGHGQQDLF 180
RVLKAYTLYR PEEGYCQAQA PIAAVLLMHM PAEQAFWCLV QVCEKYLPGY YSEKLEAIQL 240
DGEILFSLLQ KVSPVAHKHL SRQKIDPLLY MTEWFMCAFA RTLPWSSVLR VWDMFFCEGV 300
KIIFRVGLVL LKHALGSPEK LKACQGQYET IEQLRSLSPK IMQEAFLVQE VIELPVTERQ 360
IEREHLIQLR RWQETRGELE CRSLPRMHGA KAILDAEPGP RPALQPSPSI RLPPDAALLS 420
SKAKPHKQAQ KEQKRTKTSA QLDKSPGLSQ ATVVTAAGDA CPPQGVSPKD PVPQDPTPQN 480
LACHHSQESL TSQESEDTYL 500 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS