CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019283
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UPF0420 protein C16orf58 
Protein Synonyms/Alias
  
Gene Name
 C16orf58 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51LSRAFTVKPEGRDAGubiquitination[1, 2]
297GRLRLVLKHYLQRGEubiquitination[2, 3, 4]
376LNQKAGPKTILRAATubiquitination[2]
414RVRAGPKKESWVVVKubiquitination[2]
433VLDMLFPKFLKGLQDubiquitination[1, 2, 3, 4, 5]
436MLFPKFLKGLQDAGWubiquitination[2, 3, 4]
444GLQDAGWKTEKHQLEubiquitination[2]
447DAGWKTEKHQLEVDEubiquitination[1, 2]
465TWLLSPEKKVL****ubiquitination[3, 4]
466WLLSPEKKVL*****ubiquitination[2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 468 AA 
Protein Sequence
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV 60
GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG 120
VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI 180
MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL 240
AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL 300
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ 360
SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV 420
KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL 468 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR006968; DUF647. 
Pfam
 PF04884; DUF647 
SMART
  
PROSITE
  
PRINTS