| Tag | Content |
|---|
| CPLM ID | CPLM-005477 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin beta-7 |
Protein Synonyms/Alias | Gut homing receptor beta subunit |
Gene Name | ITGB7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 165 | MDLSYSMKDDLERVR | ubiquitination | [1] | | 199 | GFGSFVDKTVLPFVS | ubiquitination | [1] | | 211 | FVSTVPSKLRHPCPT | ubiquitination | [1] | | 299 | FHTAGDGKLGGIFMP | ubiquitination | [1] | | 642 | CDQCPGCKTPCERHR | ubiquitination | [1] | | 763 | REYSRFEKEQQQLNW | ubiquitination | [1] | | 771 | EQQQLNWKQDSNPLY | ubiquitination | [1] | | 779 | QDSNPLYKSAITTTI | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. |
Sequence Annotation | DOMAIN 150 389 VWFA.
REPEAT 478 526 I.
REPEAT 527 565 II.
REPEAT 566 604 III.
REPEAT 605 640 IV.
REGION 478 640 Cysteine-rich tandem repeats.
METAL 159 159 Magnesium; MIDAS motif (By similarity).
METAL 161 161 Magnesium; MIDAS motif (By similarity).
METAL 163 163 Magnesium; MIDAS motif (By similarity).
METAL 166 166 Magnesium or calcium; ADMIDAS motif (By
METAL 167 167 Magnesium or calcium; ADMIDAS motif (By
METAL 198 198 Magnesium; LIMBS motif (By similarity).
METAL 254 254 Magnesium; LIMBS motif (By similarity).
METAL 256 256 Magnesium; LIMBS motif (By similarity).
METAL 259 259 Magnesium; LIMBS motif (By similarity).
METAL 289 289 Magnesium; MIDAS motif (By similarity).
MOD_RES 778 778 Phosphotyrosine; by Tyr-kinases (By
CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
CARBOHYD 279 279 N-linked (GlcNAc...) (Potential).
CARBOHYD 434 434 N-linked (GlcNAc...) (Potential).
CARBOHYD 477 477 N-linked (GlcNAc...) (Potential).
CARBOHYD 531 531 N-linked (GlcNAc...) (Potential).
CARBOHYD 590 590 N-linked (GlcNAc...) (Potential).
CARBOHYD 665 665 N-linked (GlcNAc...) (Potential).
CARBOHYD 674 674 N-linked (GlcNAc...) (Potential).
DISULFID 45 476 By similarity.
DISULFID 51 61 By similarity.
DISULFID 54 91 By similarity.
DISULFID 64 80 By similarity.
DISULFID 216 223 By similarity.
DISULFID 271 311 By similarity.
DISULFID 412 428 By similarity.
DISULFID 448 688 By similarity.
DISULFID 474 478 By similarity.
DISULFID 488 500 By similarity.
DISULFID 497 537 By similarity.
DISULFID 502 511 By similarity.
DISULFID 513 527 By similarity.
DISULFID 543 548 By similarity.
DISULFID 545 574 By similarity.
DISULFID 550 559 By similarity.
DISULFID 561 566 By similarity.
DISULFID 580 585 By similarity.
DISULFID 582 613 By similarity.
DISULFID 587 596 By similarity.
DISULFID 598 605 By similarity.
DISULFID 619 624 By similarity.
DISULFID 621 666 By similarity.
DISULFID 626 635 By similarity.
DISULFID 638 641 By similarity.
DISULFID 645 654 By similarity. |
Keyword | 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Integrin; Magnesium; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 798 AA |
Protein Sequence | MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS 60
CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA 120
TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV 180
RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ 240
AFEREVGRQS VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 300
GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS AALPVYQELS 360
KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL PPGVHISYES QCEGPEKREG 420
KAEDRGQCNH VRINQTVTFW VSLQATHCLP EPHLLRLRAL GFSEELIVEL HTLCDCNCSD 480
TQPQAPHCSD GQGHLQCGVC SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK 540
GHCQCGRCSC SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG 600
DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD CAECGAFRTG 660
PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF LVEDDARGTV VLRVRPQEKG 720
ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV EIYDRREYSR FEKEQQQLNW KQDSNPLYKS 780
AITTTINPRF QEADSPTL 798 |
Gene Ontology | GO:0008305; C:integrin complex; TAS:ProtInc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004872; F:receptor activity; IEA:InterPro. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0007160; P:cell-matrix adhesion; IEA:InterPro. GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. GO:0050900; P:leukocyte migration; IEA:Compara. GO:0007275; P:multicellular organismal development; IEA:InterPro. GO:0050776; P:regulation of immune response; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |