| Tag | Content |
|---|
| CPLM ID | CPLM-024413 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UV excision repair protein RAD23 homolog A |
Protein Synonyms/Alias | |
Gene Name | RAD23A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Bos taurus (Bovine) |
NCBI Taxa ID | 9913 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 16 | TLQQQTFKIRMEPDE | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). |
Sequence Annotation | DOMAIN 1 81 Ubiquitin-like.
DOMAIN 161 201 UBA 1.
DOMAIN 317 357 UBA 2.
MOD_RES 123 123 Phosphoserine (By similarity).
MOD_RES 133 133 Phosphoserine (By similarity).
MOD_RES 205 205 Phosphoserine (By similarity).
MOD_RES 294 294 Phosphoserine (By similarity).
MOD_RES 356 356 Phosphoserine (By similarity).
CROSSLNK 122 122 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Complete proteome; DNA damage; DNA repair; Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 362 AA |
Protein Sequence | MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 60
IRDYRIDEKN FVVVMVTKAK TSPGTSVPSE ASPTATPESS TSFPSAPASG MSHPPPTARE 120
DKSPSEESAP TTSPESVSGS VPSSGSGGRE EDAASTLVTG SEYETMLTEI MSMGYERERV 180
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPSTEAGENP LEFLRDQPQF 240
QNMRQVIQQN PALLPALLQQ LGQENPQLLQ QISRHQEQFI QMLNEPPGEL VDISDVEGEV 300
GAIGEEAPQM NYIQVTPQEK EAIERLKALG FPESLVIQAY FACEKNENLA ANFLLSQNFD 360
DE 362 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. GO:0003684; F:damaged DNA binding; IEA:InterPro. GO:0006289; P:nucleotide-excision repair; IEA:InterPro. GO:0045070; P:positive regulation of viral genome replication; IEA:Compara. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro. GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |