CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011658
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine permease SAM3 
Protein Synonyms/Alias
 S-adenosylmethionine metabolism protein 3 
Gene Name
 SAM3 
Gene Synonyms/Alias
 YPL274W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
12KRGNESDKFTKIETEubiquitination[1]
15NESDKFTKIETESTTubiquitination[1]
42RRMKDSFKQSNLHVIubiquitination[1]
63SEQTEQEKIQWKLASubiquitination[1]
67EQEKIQWKLASQPYQubiquitination[1]
75LASQPYQKVLSQRHLubiquitination[1]
563VENLELFKAQKEAEEubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source. 
Sequence Annotation
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 44 44 Phosphoserine.
 CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
 CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).  
Keyword
 Amino-acid transport; Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MDILKRGNES DKFTKIETES TTIPNDSDRS GSLIRRMKDS FKQSNLHVIP EDLENSEQTE 60
QEKIQWKLAS QPYQKVLSQR HLTMIAIGGT LGTGLFIGLG YSLASGPAAL LIGFLLVGTS 120
MFCVVQSAAE LSCQFPVSGS YATHVSRFID ESVGFTVATN YALAWLISFP SELIGCALTI 180
SYWNQTVNPA VWVAIFYVFI MVLNLFGVRG FAETEFALSI IKVIAIFIFI IIGIVLIAGG 240
GPNSTGYIGA KYWHDPGAFA KPVFKNLCNT FVSAAFSFGG SELVLLTSTE SKNISAISRA 300
AKGTFWRIAI FYITTVVIIG CLVPYNDPRL LSGSNSEDVS ASPFVIALSN TGSMGAKVSN 360
FMNVVILVAV VSVCNSCVYA SSRLIQALGA SGQLPSVCSY MDRKGRPLVG IGISGAFGLL 420
GFLVASKKED EVFTWLFALC SISSFFTWFC ICMSQIRFRM ALKAQGRSND EIAYKSILGV 480
YGGILGCVLN ALLIAGEIYV SAAPVGSPSS AEAFFEYCLS IPIMIVVYFA HRFYRRDWKH 540
FYIKRSEIDL DTGCSVENLE LFKAQKEAEE QLIASKPFYY KIYRFWC 587 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0015489; F:putrescine transmembrane transporter activity; IDA:SGD.
 GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; IMP:SGD.
 GO:0015606; F:spermidine transmembrane transporter activity; IDA:SGD. 
Interpro
 IPR004841; AA-permease_dom.
 IPR002293; AA/rel_permease1.
 IPR004762; Amino_acid_permease_fungi.
 IPR004840; Amoino_acid_permease_CS. 
Pfam
 PF00324; AA_permease 
SMART
  
PROSITE
 PS00218; AMINO_ACID_PERMEASE_1 
PRINTS