CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036904
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 CD44 antigen 
Protein Synonyms/Alias
  
Gene Name
 CD44 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54TEAADLCKAFNSTLPubiquitination[1]
158DGTRYVQKGEYRTNPubiquitination[1, 2]
653RRCGQKKKLVINSGNubiquitination[2, 3]
667NGAVEDRKPSGLNGEubiquitination[1, 2, 3]
677GLNGEASKSQEMVHLubiquitination[1, 2, 3]
687EMVHLVNKESSETPDubiquitination[1, 2, 3]
711NLQNVDMKIGV****ubiquitination[1, 2, 3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 714 AA 
Protein Sequence
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL 60
PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN 120
ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS 180
GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE 240
TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 300
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTADVDR NGTTAYEGNW 360
NPEAHPPLIH HEHHEEEETP HSTSTIQATP SSTTEETATQ KEQWFGNRWH EGYRQTPKED 420
SHSTTGTAAA SAHTSHPMQG RTTPSPEDSS WTDFFNPISH PMGRGHQAGR RMDMDSSHSI 480
TLQPTANPNT GLVEDLDRTG PLSMTTRNRN DVTGGRRDPN HSEGSTTLLE GYTSHYPHTK 540
ESRTFIPVTS AKTGSFGVTA VTVGDSNSNV NRSLSGDQDT FHPSGGSHTT HGSESDGHSH 600
GSQEGGANTT SGPIRTPQIP EWLIILASLL ALALILAVCI AVNSRRRCGQ KKKLVINSGN 660
GAVEDRKPSG LNGEASKSQE MVHLVNKESS ETPDQFMTAD ETRNLQNVDM KIGV 714 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:InterPro. 
Interpro
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR001231; CD44_antigen.
 IPR000538; Link. 
Pfam
 PF00193; Xlink 
SMART
 SM00445; LINK 
PROSITE
 PS01241; LINK_1
 PS50963; LINK_2 
PRINTS
 PR00658; CD44.
 PR01265; LINKMODULE.