CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043195
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein unc-13 homolog B 
Protein Synonyms/Alias
  
Gene Name
 Unc13a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1130MNLHFKVKWLYNEYVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1731 AA 
Protein Sequence
MSLLCVGVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM FEINRLDLGL 60
TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQAIMADSEI CGTKDPTFHR 120
ILLDAHFELP LDIPEEEARY WAKKLEQLNA MRDQDEYSFQ DQQDKPLPVP SSQCCNWNYF 180
GWGEQNDDPD SAVDDRDSDY RSETSNSIPP PYYTTSQPNA SVHQYSVRPP PLGSRESYSD 240
SMHSYEEFSE PRALSPTGSS RYASSGELSQ GSSQLSEDFD PDEHSLQGSE LDDERDRDSY 300
HSCHSSVSYH KDSPRWDQDD EDLEDLEDLE DEELPEEEEE LEEEGEEELE EEDLEEEEEV 360
PDDLASYTQQ EDTTVAEPKE FKRISFPTAA PQKDDKVSAV PTEAPEVAKG IPKAATPEEK 420
AAAERAQEAE PPKSEESFRS REEEEGQEGQ DAMSRAKANW LRAFNKVRMQ LQEARGEGDM 480
SKSLWFKGGP GGGLIIIDSM PDIRKRKPIP LVSDLAMSLV QSRKAGITSA LASSTLNNEE 540
LKNHVYKKTL QALIYPISCT TPHNFEVWTA TTPTYCYECE GLLWGIARQG MRCTECGVKC 600
HEKCQDLLNA DCLQRAAEKS SKHGAEDRTQ NIIMVLKDRM KIRERNKPEI FELIQEIFAV 660
TKSAHTQQMK AVKQSVLDGT SKWSAKISIT VVCAQGLQAK DKTGSSDPYV TVQVGKTKKR 720
TKTIYGNLNP VWEENFHFEC HNSSDRIKVR VWDEDDDIKS RVKQRFKRES DDFLGQTIIE 780
VRTLSGEMDV WYNLDKRTDK SAVSGAIRLH ISVEIKGEEK VAPYHVQYTC LHENLFHFVT 840
DVQNNGVVKI PDAKGDDAWK VYYDETAQEI VDEFAMRYGV ESIYQAMTHF ACLSSKYMCP 900
GVPAVMSTLL ANINAYYAHT TASTNVSASD RFAASNFGKE RFVKLLDQLH NSLRIDLSMY 960
RNNFPASSPE RLQDLKSTVD LLTSITFFRM KVQELQSPPR ASQVVKDCVK ACLNSTYEYI 1020
FNNCHELYGR EYQTDPAKKG EVPPEEQGPS IKNLDFWSKL ITLIVSIIEE DKNSYTPCLN 1080
QFPQELNVGK ISAEVMWSLF AQDMKYAMEE HDKHRLCKSA DYMNLHFKVK WLYNEYVAEL 1140
PTFKDRVPEY PAWFEPFVIQ WLDENEEVSR DFLHGALERD KKDGFQQTSE HALFSCSVVD 1200
VFSQLNQSFE IIKKLECPDP QIVGHYMRRF AKTISNVLLQ YADIVSKDFA SYCSKEKEKV 1260
PCILMNNTQQ LRVQLEKMFE AMGGKELDAE ASGTLKELQV KLNNVLDELS HVFATSFQPH 1320
IEECVRQMGD ILSQVKGTGN VPASACSSVA QDADNVLQPI MDLLDSNLTL FAKICEKTVL 1380
KRVLKELWKL VMNTMEKTIV LPPLTDQTMI GTLLRKHGKG LEKGRVKLPS HSDGTQMIFN 1440
AAKELGQLSK LKDHMVREEA KSLTPKQCAV VELALDTIKQ YFHAGGVGLK KTFLEKSPDL 1500
QSLRYALSLY TQATDLLIKT FVQTQSAQVH GGKGTRFTLS EDVCPEMGSG VEDPVGEVSV 1560
HVELFTHPGT GEQKVTVKVV AANDLKWQTS GIFRPFIEVN IVGPQLSDKK RKFATKSKNN 1620
SWAPKYNESF QFSLSADAGP ECYELQVCVK DYCFAREDRT VGLAVLQLRE LAQRGSAACW 1680
LPLGRRIHMD DTGLTVLRIL SQRSNDEVAK EFVKLKSDTR SAEEGGAAPA P 1731 
Gene Ontology
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0019992; F:diacylglycerol binding; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050435; P:beta-amyloid metabolic process; IMP:MGI.
 GO:0060384; P:innervation; IGI:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007528; P:neuromuscular junction development; IGI:MGI.
 GO:0001956; P:positive regulation of neurotransmitter secretion; IMP:MGI.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IMP:MGI.
 GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.
 GO:0016081; P:synaptic vesicle docking involved in exocytosis; IGI:MGI.
 GO:0016188; P:synaptic vesicle maturation; IMP:MGI.
 GO:0016082; P:synaptic vesicle priming; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR014772; Munc13_dom-2.
 IPR019558; Munc13_subgr_dom-2.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR027080; Unc-13.
 IPR027082; Unc13A. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF06292; DUF1041
 PF10540; Membr_traf_MHD 
SMART
 SM00109; C1
 SM00239; C2 
PROSITE
 PS50004; C2
 PS51258; MHD1
 PS51259; MHD2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.