CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025244
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activin A receptor, type 1B 
Protein Synonyms/Alias
  
Gene Name
 Acvr1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
215VLQEIIGKGRFGEVWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Kinase; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD 60
GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS 120
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 360
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 420
GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN 480
GAARLTALRI KKTLSQLSVQ EDVKI 505 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0017002; F:activin-activated receptor activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:Compara.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
 GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; TAS:MGI.
 GO:0032924; P:activin receptor signaling pathway; IDA:MGI.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0046545; P:development of primary female sexual characteristics; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0007498; P:mesoderm development; ISA:MGI.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0038092; P:nodal signaling pathway; IEA:Compara.
 GO:0032927; P:positive regulation of activin receptor signaling pathway; IEA:Compara.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:1901165; P:positive regulation of trophoblast cell migration; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0009966; P:regulation of signal transduction; IDA:MGI. 
Interpro
 IPR000472; Activin_rcpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR003605; TGF_beta_rcpt_GS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase
 PF08515; TGF_beta_GS 
SMART
 SM00467; GS 
PROSITE
 PS51256; GS
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS