UniProt Accession

 A1AT3_MOUSE; Q00896; P81105; Q91V74; Q91WH5; Q91XC1 

Genbank Protein ID

 M75720; BC009818; BC010984; BC010988; BC011041; BC015266; BC021325; BC021780; BC024108; BC031707; X00945 

Genbank Nucleotide ID

 AAC28868.1; AAH09818.1; AAH10984.1; AAH10988.1; AAH11041.1; AAH15266.1; AAH21325.1; AAH21780.1; AAH24108.1; AAH31707.1; CAA25457.1 

Protein Name

 Alpha-1-antitrypsin 1-3 

Protein Synonyms/Alias

 Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c 

Gene Name

 Serpina1c 

Gene Synonyms/Alias

 Dom3; Dom6; Spi1-3; Spi1-6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
186	VEKGTQGKIVEAVKK	ubiquitination	[1]
292	LSKELISKFLLNRRR	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. 

Sequence Annotation

 REGION 368 387 RCL.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...).  

Keyword

 Complete proteome; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IDA:MGI.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0034097; P:response to cytokine stimulus; IDA:MGI.
 GO:0043434; P:response to peptide hormone stimulus; IDA:MGI. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS