CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032891
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cleavage and polyadenylation specific factor 3-like, isoform CRA_i 
Protein Synonyms/Alias
 Integrator complex subunit 11 
Gene Name
 CPSF3L 
Gene Synonyms/Alias
 hCG_20422 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136ETVERGGKVLIPVFAubiquitination[1, 2, 3]
164FWERMNLKVPIYFSTubiquitination[1, 2, 4]
176FSTGLTEKANHYYKLubiquitination[1]
182EKANHYYKLFIPWTNubiquitination[5]
191FIPWTNQKIRKTFVQubiquitination[1, 5]
205QRNMFEFKHIKAFDRubiquitination[1]
320LLVHGEAKKMEFLKQubiquitination[4]
328KMEFLKQKIEQELRVubiquitination[1]
376QGLLPEAKKPRLLHGubiquitination[1, 3]
377GLLPEAKKPRLLHGTubiquitination[1]
388LHGTLIMKDSNFRLVubiquitination[1, 3, 4, 5]
402VSSEQALKELGLAEHubiquitination[1, 2, 3, 4, 5, 6]
437LRVYSHLKSVLKDHCubiquitination[1]
495FLTSLLKKGLPQAPSubiquitination[7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 502 AA 
Protein Sequence
MPEIRVTPLG ACPVLSWNLV LPPGRGSRAP SSTDTRTGFH VLPHGVDDEL EIKAYYAGHV 60
LGAAMFQIKV GSESVVYTGD YNMTPDRHLG AAWIDKCRPN LLITESTYAT TIRDSKRCRE 120
RDFLKKVHET VERGGKVLIP VFALGRAQEL CILLETFWER MNLKVPIYFS TGLTEKANHY 180
YKLFIPWTNQ KIRKTFVQRN MFEFKHIKAF DRAFADNPGP MVVFATPGML HAGQSLQIFR 240
KWAGNEKNMV IMPGYCVQGT VGHKILSGQR KLEMEGRQVL EVKMQVEYMS FSAHADAKGI 300
MQLVGQAEPE SVLLVHGEAK KMEFLKQKIE QELRVNCYMP ANGETVTLPT SPSIPVGISL 360
GLLKREMAQG LLPEAKKPRL LHGTLIMKDS NFRLVSSEQA LKELGLAEHQ LRFTCRVHLH 420
DTRKEQETAL RVYSHLKSVL KDHCVQHLPD GSVTVESVLL QAAAPSEDPG TKVLLVSWTY 480
QDEELGSFLT SLLKKGLPQA PS 502 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR022712; Beta_Casp.
 IPR011108; RMMBL. 
Pfam
 PF10996; Beta-Casp
 PF07521; RMMBL 
SMART
 SM01027; Beta-Casp 
PROSITE
  
PRINTS