CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016917
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein ELYS 
Protein Synonyms/Alias
 Embryonic large molecule derived from yolk sac; Protein MEL-28; Putative AT-hook-containing transcription factor 1 
Gene Name
 Ahctf1 
Gene Synonyms/Alias
 Elys 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
969ANYISALKLNQILKNubiquitination[1]
1002SILDQYGKILPRVQRubiquitination[1]
2221KTAEIAGKTLGRGRKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839). 
Sequence Annotation
 DNA_BIND 1955 1967 A.T hook.
 REGION 1 981 Necessary for cytoplasmic localization.
 REGION 1149 2243 Necessary for nuclear localization.
 REGION 1447 1694 Mediates transcriptional activity.
 MOD_RES 528 528 Phosphoserine (By similarity).
 MOD_RES 1142 1142 Phosphoserine (By similarity).
 MOD_RES 1150 1150 Phosphoserine (By similarity).
 MOD_RES 1155 1155 Phosphoserine (By similarity).
 MOD_RES 1175 1175 Phosphothreonine (By similarity).
 MOD_RES 1214 1214 Phosphoserine (By similarity).
 MOD_RES 1235 1235 Phosphoserine (By similarity).
 MOD_RES 1381 1381 Phosphoserine.
 MOD_RES 1517 1517 Phosphothreonine (By similarity).
 MOD_RES 1533 1533 Phosphoserine (By similarity).
 MOD_RES 1541 1541 Phosphoserine (By similarity).
 MOD_RES 1725 1725 Phosphoserine (By similarity).
 MOD_RES 1864 1864 Phosphoserine (By similarity).
 MOD_RES 1870 1870 Phosphoserine (By similarity).
 MOD_RES 1884 1884 Phosphoserine (By similarity).
 MOD_RES 1928 1928 Phosphoserine (By similarity).
 MOD_RES 1930 1930 Phosphoserine (By similarity).
 MOD_RES 1980 1980 Phosphoserine (By similarity).
 MOD_RES 2021 2021 Phosphoserine (By similarity).
 MOD_RES 2132 2132 Phosphoserine (By similarity).
 MOD_RES 2188 2188 Phosphoserine (By similarity).
 MOD_RES 2198 2198 Phosphoserine (By similarity).
 MOD_RES 2202 2202 Phosphoserine (By similarity).  
Keyword
 3D-structure; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Developmental protein; DNA-binding; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transcription; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2243 AA 
Protein Sequence
MQDLTAQVTS DLLHFPEVTI EALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSL 60
TGERLSAYRF SGVNEQPPVV LAVKEFSWHK RTGLLIGLEE ADGSVLCLYD LGISRVVKAV 120
VLPGRVTAIE PIINHGGASA STQHLHPSLR WLFGVAAVVT DVGQILLIDL CLDDLSCSQN 180
EVEASDLEVI TGIPAEVPHI RERVMREGRH LCFQLVSPLG VAISTLSYIN RTNQLAVGFS 240
DGYLALWNMK SMKREYYTQL EGGRVPVHAV AFQEPENDPR NCCYLWAVQS TQDSEGDVLS 300
LHLLQLAFGD RKCLASGQIL YEGLEYCEER YTLDLAGGTF PLRGQTSNTK LLGCQSIERF 360
PSHGDREESM REALSPDTSV SVFTWQVNIY GQGKPSVYLG LFDINRWYHA QMPDSLRSGE 420
SLHNCSYFAL WSLDSVVSRT SPHHILDILV HERSLNRGVP PSYPPPEQFF NPSTFNFDAT 480
CLLDSGVIHV TCAGFQKETL TFLKKSGPTL NEVIPDSYNR CLVAGLLSPR LIDIQPSSLS 540
QEEQLEAILS AAIQTSSLGL LTGYIRTWII EEQPNSAANL RFVLEWTWNK VVLTKEEFDR 600
LCVPLFDGSC RFIDPQTIQS IQQCHLLLSN LSTVLSCFAM EAQGITERGL VDLSNKHMVT 660
QLLCQYAHMV LWFCHSGLLP EGLDDALQLS RLRYNYPVIQ NYYTSRRQKS ERSPRGKWNH 720
DCLMIDGLVS QLGDEVEKLW KRDEGGTGRY PPASIHALLD IYLLDNITEA SKHAITIYLL 780
LDIMYSFPNK TDTPIESFPT AFAISWGQVK LVQGFWLLDH NDYENGLDLL FHPVTAKPAS 840
WQHSKIIEAF MSQGEHKQAL RYLQTMKPTV SSSNEVILHL TVLLFNRCMV EAWNLLRQNS 900
NRVNIEELLK HAYEVCQEMG LMEDLLKLPF TNTEQECLVK FLQSSTSVEN HEFLLVHHLQ 960
RANYISALKL NQILKNNLMS DRDPRLRERS VTRNSILDQY GKILPRVQRK LAVERAKPYH 1020
LSTSSVFHEV SRPKPLSAFP KKAITGTVLT RSTFISNVLS KIGEVWASHE PRNGVSLFNS 1080
PKTEQPSPVV HSFPHPELPE AFVGTPISNT SQRISRLLDL VVHPVPQPSQ CLEFIQQSPT 1140
RSPLCLLSSS LPLSSQFKRP HQNTSRPSEL LLLETPLIVK KAKSLALSAT SSGFAEFTPP 1200
SILRSGFRTT PLASPSLSPG RSLTPPFRVK ETRISFMEEG MNTHWTDRAT DDRNTKAFVS 1260
TSFHKCGLPA ETEWMKTSDK NTYFPLDVPA KGPQKVVAES LATHSGRLEK LDVSKEDSTA 1320
STRSDQTSLE YHDAPSPEDL EGAVFVSPKP ASSSTELTTN STLQTERDND KDAFKSEGAP 1380
SPVKKQIGTG DAAVEAFSEL SRLDPVERAE ASFAVSSVCE GETSTSNSKT SVLDGIVPIE 1440
SRTSILTADH KESVANTVAD VESSGSTSSK CPVTSERSLG QKLTLNLKED EIEAHVPKEN 1500
VGLPEESPRI SAAPSDTHEI HLIGCENLEV QNSEEEAKNL SFDELYPLGA EKLEYNLSTI 1560
EQQFCDLPDD KDSAECDAAE VDGELFVAQS NFTLILEGEE GEAEASDSAA PNMLPKATKE 1620
KPVCHREPHN QERVTDLPSA VTADQESHKV ETLPYVPEPV KVAIAENLLD VIKDTRSKEA 1680
TPVAAGEAGD EDGAVIVSKA AHSSRLTNST PKTVKEPHAE TVNTSQNDDM VSSRTLTRRQ 1740
HALSLNVTSE QEPSAVATPK KRTRKIKETP ESSERTCSDL KVAPENQLTA QSPPAPRRGK 1800
KKDVSQGTLP SSGAVEPEPE PQGTPGRLRL RTQPPEPAAE ETPSRTKVRL SSVRKGTPRR 1860
LKKSVENGQS TEILDDLKGS EAASHDGTVT ELRNANLEDT QNMEYKQDEH SDQQLPLKRK 1920
RVREREVSVS SVTEEPKLDS SQLPLQTGLD VPATPRKRGR PRKVVPLEAD GGTTGKEQTS 1980
PQKKDVPVVR RSTRNTPARN VSTLEKSVLV PNKEAALVVT SKRRPTKKSA EESSKDPSAA 2040
VSDLAGGAAH TESADRRDGL LAAAALTPSA QGTRTRSRRT MLLTDISEPK TEPLFPPPSV 2100
KVPKKKSKAE NMEAAAQLKE LVSDLSSQFV VSPPALRTRQ KSISNTSKLL GELESDPKPL 2160
EIIEQKPKRS RTVKTRASRN TGKGSSWSPP PVEIKLVSPL ASPVDEIKTG KPRKTAEIAG 2220
KTLGRGRKKP SSFPKQILRR KML 2243 
Gene Ontology
 GO:0000785; C:chromatin; IEA:Compara.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016363; C:nuclear matrix; IDA:MGI.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0031080; C:nuclear pore outer ring; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:MGI.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0030097; P:hemopoiesis; TAS:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; TAS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR025151; ELYS_dom. 
Pfam
 PF13934; ELYS 
SMART
 SM00384; AT_hook 
PROSITE
  
PRINTS