| Tag | Content |
|---|
| CPLM ID | CPLM-020134 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | EF-hand calcium-binding domain-containing protein 4B |
Protein Synonyms/Alias | Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A |
Gene Name | EFCAB4B |
Gene Synonyms/Alias | CRACR2A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 529 | PRGQPVGKEALCKEE | ubiquitination | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
Sequence Annotation | DOMAIN 54 82 EF-hand 1.
DOMAIN 84 119 EF-hand 2. |
Keyword | Adaptive immunity; Alternative splicing; Calcium; Calcium transport; Coiled coil; Complete proteome; Cytoplasm; Immunity; Ion transport; Metal-binding; Polymorphism; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 395 AA |
Protein Sequence | MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ 60
TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ 120
NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK 180
QLWLQLKKEE PHLLSNFEDF LTRIISQLQE AHEEKNELEC ALKRKIAAYD EEIQHLYEEM 240
EQQIKSEKEQ FLLKDTERFQ ARSQELEQKL LCKEQELEQL TQKQKRLEGQ CTALHHDKHE 300
TKAENTKLKL TNQELARELE RTSWELQDAQ QQLESLQQEA CKLHQEKEME VYRVTESLQR 360
EKAGLLKQLD FLRERNKHLR DERDICFQKN KAAKANTAAS RASWKKRSGS VIGKYVDSRG 420
ILRSQSEEEE EVFGIPRRSS LGLSGYPLTE EEPGTGEPGP GGPYPRPLRR IISVEEDPLP 480
QLLDGGFEQP LSKCSEEEEV SDQGVQGQIP EAPPLKLTPT SPRGQPVGKE ALCKEESSPS 540
APDRLFKIVF VGNSAVGKTS FLRRFCEDRF SPGMAATVGI DYRVKTLNVD NSQVALQLWD 600
TAGQERYRCI TQQFFRKADG VIVMYDLTDK QSFLSVRRWL SSVEEAVGDR VPVLLLGNKL 660
DNEKEREVPR GLGEQLATEN NLIFYECSAY SGHNTKESLL HLARFLKEQE DTVREDTIQV 720
GHPAKKKSCC G 731 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:HPA. GO:0005730; C:nucleolus; IDA:HPA. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0032237; P:activation of store-operated calcium channel activity; IMP:UniProtKB. GO:0051928; P:positive regulation of calcium ion transport; IMP:UniProtKB. GO:0002115; P:store-operated calcium entry; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |