| Tag | Content |
|---|
| CPLM ID | CPLM-014208 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myosin-binding protein C, fast-type |
Protein Synonyms/Alias | Fast MyBP-C; C-protein, skeletal muscle fast isoform |
Gene Name | Mybpc2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 19 | SKGKDAPKEAPAKQT | ubiquitination | [1] | | 24 | APKEAPAKQTPEEPP | ubiquitination | [1] | | 63 | SVSVETGKDAVILAK | ubiquitination | [1] | | 74 | ILAKVNGKELPGKPT | ubiquitination | [1] | | 79 | NGKELPGKPTIKWFK | ubiquitination | [1] | | 88 | TIKWFKGKWQELGSK | ubiquitination | [1] | | 95 | KWQELGSKSGARFIF | ubiquitination | [1] | | 165 | GQSLESFKRSGDGKS | ubiquitination | [1] | | 171 | FKRSGDGKSEDAGEL | ubiquitination | [1] | | 185 | LDFSGLLKKREVVEE | ubiquitination | [1] | | 223 | AKKSEYEKIAFQYGI | ubiquitination | [1] | | 256 | KSAAFTKKLDPAYQV | ubiquitination | [1] | | 268 | YQVDRGNKIKLVVEI | ubiquitination | [1] | | 286 | DLPLKWFKNGQEIKP | ubiquitination | [1] | | 304 | YVFENVGKKRILTIN | ubiquitination | [1] | | 387 | MTREDSYKARYRFKK | ubiquitination | [1] | | 468 | KVTGKWYKNGVEVRP | ubiquitination | [1] | | 1017 | SDSPGVSKNTARILK | ubiquitination | [1] | | 1044 | HDFRTAPKFLTPLMD | ubiquitination | [1] | | 1078 | KPKVVWMKNKMEIHE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity). |
Sequence Annotation | DOMAIN 46 149 Ig-like C2-type 1.
DOMAIN 250 339 Ig-like C2-type 2.
DOMAIN 340 432 Ig-like C2-type 3.
DOMAIN 433 533 Ig-like C2-type 4.
DOMAIN 534 633 Ig-like C2-type 5.
DOMAIN 634 726 Fibronectin type-III 1.
DOMAIN 731 824 Fibronectin type-III 2.
DOMAIN 833 927 Ig-like C2-type 6.
DOMAIN 927 1020 Fibronectin type-III 3.
DOMAIN 1043 1136 Ig-like C2-type 7. |
Keyword | 3D-structure; Actin-binding; Cell adhesion; Complete proteome; Immunoglobulin domain; Muscle protein; Reference proteome; Repeat; Thick filament. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1136 AA |
Protein Sequence | MPEAKPAAKK ASKGKDAPKE APAKQTPEEP PKEAPPEDQS PTAEEPTGIF LKKPDSVSVE 60
TGKDAVILAK VNGKELPGKP TIKWFKGKWQ ELGSKSGARF IFKESHDSTS NVYTVELHIG 120
KVVLGDRGDY RLEIKAKDVC DSCSFNVDVE APRQDSSGQS LESFKRSGDG KSEDAGELDF 180
SGLLKKREVV EEEKKKKKDD DDLGIPPEIW ELLKGAKKSE YEKIAFQYGI TDLRGMLKRL 240
KKAKVEVKKS AAFTKKLDPA YQVDRGNKIK LVVEISDPDL PLKWFKNGQE IKPSSKYVFE 300
NVGKKRILTI NKCTLADDAA YEVAVQDEKC FTELFVKEPP VLIVTPLEDQ QVFVGDRVEM 360
SVEVSEEGAQ VMWMKDGVEM TREDSYKARY RFKKDGKRHI LIYSDVAQED GGRYQVITNG 420
GQCEAELIVE EKQLEVLQDI ADLTVKAAEQ AVFKCEVSDE KVTGKWYKNG VEVRPSKRIT 480
ISHVGRFHKL VIDDVRPEDE GDYTFVPDGY ALSLSAKLNF LEIKVEYVPK QEPPKIHLDC 540
SGKTSDNSIV VVAGNKLRLD VAITGEPPPT ATWLRGDEVF TATEGRTHIE QRPDCSSFVI 600
ESAERSDEGR YTIKVTNPVG EDVASIFLRV VDVPDPPEAV RVTSVGEDWA ILVWEPPKYD 660
GGQPVTGYLM ERKKKGSQRW MKINFEVFTD TTYESTKMIE GVLYEMRVFA VNAIGVSQPS 720
MNTKPFMPIA PTSAPQHLTV EDVTDTTTTL KWRPPDRIGA GGIDGYLVEY CLEGSEEWVP 780
ANKEPVERCG FTVKDLPTGA RILFRVVGVN IAGRSEPATL LQPVTIREIV EQPKIRLPRH 840
LRQTYIRKVG EALNLVIPFQ GKPRPQVVWT KGGAPLDTSR VNVRTSDFDT VFFVRQAARS 900
DSGEYELSVQ IENMKDTATI RIRVVEKAGP AENVMVKEVW GTNALVEWQP PKDDGNSEIT 960
GYFVQKADKK TMEWFNVYEH NRHTSCTVSD LIVGNEYYFR IFSENICGLS DSPGVSKNTA 1020
RILKTGITLK PLEYKEHDFR TAPKFLTPLM DRVVVAGYTA ALNCAVRGHP KPKVVWMKNK 1080
MEIHEDPKFL ITNYQGILTL NIRRPSPFDA GTYSCRAFNE LGEALAECKL DVRVPQ 1136 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |