UniProt Accession

 CP1B1_MOUSE; Q64429; Q3UVA8; Q60593; Q64461 

Genbank Protein ID

 U03283; X78445; AK137461; CH466537; U02479 

Genbank Nucleotide ID

 AAC52141.1; CAA55205.1; BAE23362.1; EDL38490.1; AAC52131.1 

Protein Name

 Cytochrome P450 1B1 

Protein Synonyms/Alias

 CYPIB1; Cytochrome P450CMEF; Cytochrome P450EF 

Gene Name

 Cyp1b1 

Gene Synonyms/Alias

 Cyp1-b1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
260	PVRTTFRKFEQLNRN	ubiquitination	[1]
275	FSNFVLDKFLRHRES	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 

Sequence Annotation

 METAL 470 470 Iron (heme axial ligand) (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 543 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IDA:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0006725; P:cellular aromatic compound metabolic process; IDA:MGI.
 GO:0043542; P:endothelial cell migration; IMP:MGI.
 GO:0071603; P:endothelial cell-cell adhesion; IMP:MGI.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0061298; P:retina vasculature development in camera-type eye; IMP:MGI.
 GO:0008202; P:steroid metabolic process; ISS:UniProtKB.
 GO:0009404; P:toxin metabolic process; IMP:MGI.
 GO:0006805; P:xenobiotic metabolic process; ISS:UniProtKB. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.