UniProt Accession

 COX7R_HUMAN; O14548; Q9P118 

Genbank Protein ID

 AB007618; AF127788; AY007643; BT007371; BC005251; BC007095 

Genbank Nucleotide ID

 BAA22571.1; AAF72746.1; AAG32129.1; AAP36035.1; AAH05251.1; AAH07095.1 

Protein Name

 Cytochrome c oxidase subunit 7A-related protein, mitochondrial 

Protein Synonyms/Alias

 COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1 

Gene Name

 COX7A2L 

Gene Synonyms/Alias

 COX7AR; COX7RP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	KFSGFTQKLAGAWAS	ubiquitination	[1, 2, 3]
27	AYSPQGLKPVVSTEA	ubiquitination	[2]
69	ELQKFFQKADGVPVY	acetylation	[4]
78	DGVPVYLKRGLPDQM	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen. 

Sequence Annotation

 MOD_RES 69 69 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 114 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005746; C:mitochondrial respiratory chain; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003177; Cyt_c_oxidase_su7a.
 IPR017267; Cyt_c_oxidase_su7a-rel_mt. 

Pfam

 PF02238; COX7a 

SMART

  

PROSITE

  

PRINTS