CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032302
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ITPR1 protein 
Protein Synonyms/Alias
 Inositol 1,4,5-trisphosphate receptor type 1 
Gene Name
 ITPR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144RLPALLEKNAMRVTLubiquitination[1]
168FYIQPFYKLRSIGDSubiquitination[2]
230FMKWSDNKDDILKGGubiquitination[3]
403ETLLNVIKSVTRNGRubiquitination[2]
579QKKEEILKTTCFICGubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 721 AA 
Protein Sequence
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 60
CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 120
IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 180
KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 240
RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 300
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVCNKIIFL MSFVGNCGTF TRGYRAMVLD 360
VEFLYHLLYL VICAMGLFVH EFFYSLLLFD LVYREETLLN VIKSVTRNGR SIILTAVLAL 420
ILVYLFSIVG YLFFKDDFIL EVDRLPNETA VPETGESLAS EFLFSDVCRV ESGENCSSPA 480
PREELVPAEE TEQDKEHTCE TLLMCIVTVL SHGLRSGGGV GDVLRKPSKE EPLFAARVIY 540
DLLFFFMVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVTFE 600
EHIKEEHNMW HYLCFIVLVK VKDSTEYTGP ESYVAEMIKE RNLDWFPRMR AMSLVSSDSE 660
GEQNELRNLQ EKLESTMKLV TNLSGQLSEL KDQMTEQRKQ KQRIGLLGHP PHMNVNPQQP 720
A 721 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
 GO:0048016; P:inositol phosphate-mediated signaling; IEA:GOC. 
Interpro
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.