CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 
Protein Synonyms/Alias
 Pyruvate dehydrogenase complex component E1 beta; PDHE1-B 
Gene Name
 PDB1 
Gene Synonyms/Alias
 YBR221C; YBR1511 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
77NGAYKVSKGLLDRFGacetylation[1]
145YMSGGTQKCQMVFRGacetylation[1]
264AAEILQKKYGVSAEVacetylation[1]
287LDTEAIIKTVKKTNHacetylation[1]
342DVPTPYAKELEDFAFacetylation[1]
357PDTPTIVKAVKEVLSacetylation[1]
360PTIVKAVKEVLSIE*acetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). 
Sequence Annotation
 BINDING 95 95 Thiamine pyrophosphate (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Glycolysis; Mitochondrion; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MFSRLPTSLA RNVARRAPTS FVRPSAAAAA LRFSSTKTMT VREALNSAMA EELDRDDDVF 60
LIGEEVAQYN GAYKVSKGLL DRFGERRVVD TPITEYGFTG LAVGAALKGL KPIVEFMSFN 120
FSMQAIDHVV NSAAKTHYMS GGTQKCQMVF RGPNGAAVGV GAQHSQDFSP WYGSIPGLKV 180
LVPYSAEDAR GLLKAAIRDP NPVVFLENEL LYGESFEISE EALSPEFTLP YKAKIEREGT 240
DISIVTYTRN VQFSLEAAEI LQKKYGVSAE VINLRSIRPL DTEAIIKTVK KTNHLITVES 300
TFPSFGVGAE IVAQVMESEA FDYLDAPIQR VTGADVPTPY AKELEDFAFP DTPTIVKAVK 360
EVLSIE 366 
Gene Ontology
 GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
 GO:0005967; C:mitochondrial pyruvate dehydrogenase complex; IDA:SGD.
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IMP:SGD.
 GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:SGD.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR027110; PDHB.
 IPR009014; Transketo_C/Pyr-ferredox_oxred.
 IPR015941; Transketolase-like_C.
 IPR005475; Transketolase-like_Pyr-bd.
 IPR005476; Transketolase_C. 
Pfam
 PF02779; Transket_pyr
 PF02780; Transketolase_C 
SMART
 SM00861; Transket_pyr 
PROSITE
  
PRINTS