UniProt Accession

 NRL_HUMAN; P54845; Q53XD0 

Genbank Protein ID

 M95925; M81840; U95012; BX161381; BX161522; AB593102; AB593104; AB593106; BT006942; AL136295; CH471078; BC012395 

Genbank Nucleotide ID

 AAA96828.1; AAA59948.1; AAB82768.1; CAD61873.1; CAD61954.1; BAJ84042.1; BAJ84044.1; BAJ84046.1; AAP35588.1; EAW66116.1; AAH12395.1 

Protein Name

 Neural retina-specific leucine zipper protein 

Protein Synonyms/Alias

 NRL 

Gene Name

 NRL 

Gene Synonyms/Alias

 D14S46E 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	VNDFDLMKFEVKREP	sumoylation	[1]
24	DLMKFEVKREPSEGR	sumoylation	[1]

Reference

 [1] Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.
 Roger JE, Nellissery J, Kim DS, Swaroop A.
 J Biol Chem. 2010 Aug 13;285(33):25637-44. [PMID: 20551322] 

Functional Description

 Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B (By similarity). 

Sequence Annotation

 DOMAIN 159 222 bZIP.
 REGION 30 93 Minimal transactivation domain (MTD).
 REGION 159 185 Basic motif (By similarity).
 REGION 187 208 Leucine-zipper (By similarity).
 CROSSLNK 20 20 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 24 24 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Developmental protein; Disease mutation; DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Retinitis pigmentosa; Sensory transduction; Transcription; Transcription regulation; Ubl conjugation; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045872; P:positive regulation of rhodopsin gene expression; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007468; P:regulation of rhodopsin gene expression; TAS:ProtInc.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0046548; P:retinal rod cell development; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR004827; bZIP.
 IPR004826; bZIP_Maf.
 IPR008917; Euk_TF_DNA-bd.
 IPR013592; Maf_TF_N.
 IPR024874; Transciption_factor_Maf. 

Pfam

 PF03131; bZIP_Maf
 PF08383; Maf_N 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS