CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 12 member 6 
Protein Synonyms/Alias
 cDNA FLJ46254 fis, clone TESTI4023096, highly similar to Solute carrier family 12 member 6 
Gene Name
 SLC12A6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37AENITEGKKKPTKTMubiquitination[1]
412RLLQAIAKDNIIPFLubiquitination[1, 2, 3, 4]
536IEYQGAEKEWGDGIRubiquitination[1]
565EEGPPHTKNWRPQLLubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 962 AA 
Protein Sequence
MDTRPKVSSL LNRMANYTNL TQGAKEHEEA ENITEGKKKP TKTMLTAISM SAIATNGVVP 60
AGGSYFMISR ALGPEFGGAV GLCFYLGTTF AAAMYILGAI EIFLVYIVPR AAIFHSDDAL 120
KESAAMLNNM RVYGTAFLVL MVLVVFIGVR YVNKFASLFL ACVIVSILAI YAGAIKSSFA 180
PPHFPVCMLG NRTLSSRHID VCSKTKEINN MTVPSKLWGF FCNSSQFFNA TCDEYFVHNN 240
VTSIQGIPGL ASGIITENLW SNYLPKGEII EKPSAKSSDV LGSLNHEYVL VDITTSFTLL 300
VGIFFPSVTG IMAGSNRSGD LKDAQKSIPI GTILAILTTS FVYLSNVVLF GACIEGVVLR 360
DKFGDAVKGN LVVGTLSWPS PWVIVIGSFF STCGAGLQSL TGAPRLLQAI AKDNIIPFLR 420
VFGHSKANGE PTWALLLTAA IAELGILIAS LDLVAPILSM FFLMCYLFVN LACALQTLLR 480
TPNWRPRFRY YHWALSFMGM SICLALMFIS SWYYAIVAMV IAGMIYKYIE YQGAEKEWGD 540
GIRGLSLSAA RFALLRLEEG PPHTKNWRPQ LLVLLKLDED LHVKHPRLLT FASQLKAGKG 600
LTIVGSVIVG NFLENYGEAL AAEQTIKHLM EAEKVKGFCQ LVVAAKLREG ISHLIQSCGL 660
GGMKHNTVVM GWPNGWRQSE DARAWKTFIG TVRVTTAAHL ALLVAKNISF FPSNVEQFSE 720
GNIDVWWIVH DGGMLMLLPF LLKQHKVWRK CSIRIFTVAQ LEDNSIQMKK DLATFLYHLR 780
IEAEVEVVEM HDSDISAYTY ERTLMMEQRS QMLRHMRLSK TERDREAQLV KDRNSMLRLT 840
SIGSDEDEET ETYQEKVHMT WTKDKYMASR GQKAKSMEGF QDLLNMRPDQ SNVRRMHTAV 900
KLNEVIVNKS HEAKLVLLNM PGPPRNPEGD ENYMEFLEVL TEGLERVLLV RGGGSEVITI 960
YS 962 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro. 
Interpro
 IPR004841; AA-permease_dom.
 IPR018491; K/Cl_cotranspt_1/3.
 IPR000076; KCL_cotranspt.
 IPR004842; Na/K/Cl_cotransptS. 
Pfam
 PF00324; AA_permease
 PF03522; KCl_Cotrans_1 
SMART
  
PROSITE
  
PRINTS
 PR01081; KCLTRNSPORT.