CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein-associating with the carboxyl-terminal domain of ezrin 
Protein Synonyms/Alias
 Ezrin-binding protein PACE-1; SCY1-like protein 3 
Gene Name
 Scyl3 
Gene Synonyms/Alias
 Pace1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272DEKTEFFKFLLDRVSubiquitination[1]
419VVGGERTKIFKRTAPacetylation[2]
422GERTKIFKRTAPSFTacetylation[2]
453SQQSRVSKVLEDPSSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May play a role in regulating cell adhesion/migration complexes in migrating cells. 
Sequence Annotation
 DOMAIN 2 245 Protein kinase.
 REPEAT 194 249 HEAT 1.
 REPEAT 285 323 HEAT 2.
 REPEAT 333 370 HEAT 3.
 REPEAT 372 409 HEAT 4.
 REGION 547 735 Interaction with EZR (By similarity).
 MOD_RES 475 475 Phosphoserine.
 LIPID 2 2 N-myristoyl glycine (By similarity).  
Keyword
 Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Golgi apparatus; Lipoprotein; Myristate; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 735 AA 
Protein Sequence
MGSENSALKS YTLRESPFTL PSGLAVYPAI LQDGKCASVF VYKRENEDKV NKAAKHLKTL 60
RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSPAEV CAGIYDILLA LIFLHDRGHL 120
THNNVCLSSV FVSEDGHWKL GGMETVCQVP QATPEFLRNI QSVRDPASIP PEEMSPEFSG 180
LPESHGHARD AYAFGALVDS LLPIFNEQVS ADVLSSFLQI LHSALLNPMP ECRPALSTLL 240
SHDFFRNDFL EVVNFLKSLT LKSEDEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF 300
AEPVAVKSFL PYLLGPKKEN APGETPCLLS PALFQSRVIP VLLRLFEVHE EHVRMVLLSH 360
IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSN SIVAITLRSL AVLVSLLGPE VVVGGERTKI 420
FKRTAPSFTK TSDLSPEGSP MHVVCSQQSR VSKVLEDPSS NVFPKWLSGN VPSSSRKRIQ 480
EECYSSLSQT GDQFSHTIKF PMNGLSDVKN TSEDNGSFPA GSNKPEEWPD WSEPEEPEQQ 540
PASIHRWPRE PCDVAESQHT NLTAEEVTWD DGEASFGTEI NSTATASAPV PVTSGGQSTS 600
AALVPLTEES KPLQSSPSSK TSHRQHEEVK PPQVSQERPL KAPSGLGLGE EFTIQVKKKP 660
VQDPELDWFA DMIPEIKPSG TFLILPELRT EVMVPDKDNV SSLMQFSSKF AATEMTEGEA 720
EGWEGEELAW EDNNW 735 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT
 PS50011; PROTEIN_KINASE_DOM 
PRINTS