UniProt Accession

 NPDC1_HUMAN; Q9NQX5; Q5SPY8; Q9BTD6; Q9BXT3; Q9NQS2; Q9Y434 

Genbank Protein ID

 AF272357; AF285836; AL807752; BC004217; AF283247; AL050221 

Genbank Nucleotide ID

 AAF76225.1; AAK27328.1; CAI12775.1; AAH04217.1; AAF82603.1; CAB43321.1 

Protein Name

 Neural proliferation differentiation and control protein 1 

Protein Synonyms/Alias

 NPDC-1 

Gene Name

 NPDC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
218	REIRLTQKADYATAK	ubiquitination	[1, 2, 3]
225	KADYATAKAPGSPAA	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR009635; NPDC1. 

Pfam

 PF06809; NPDC1 

SMART

  

PROSITE

  

PRINTS