UniProt Accession

 SYFA_MOUSE; Q8C0C7; Q3U3Q9; Q91WR4; Q922S1 

Genbank Protein ID

 AK031697; AK154629; BC006862; BC013533 

Genbank Nucleotide ID

 BAC27519.1; BAE32726.1; AAH06862.1; AAH13533.1 

Protein Name

 Phenylalanine--tRNA ligase alpha subunit 

Protein Synonyms/Alias

 Phenylalanyl-tRNA synthetase alpha subunit; PheRS 

Gene Name

 Farsa 

Gene Synonyms/Alias

 Farsla 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
150	VQAGQAEKLAEKERN	ubiquitination	[1]
187	AFSTSVSKQEAELSP	ubiquitination	[1]
208	SWRDRPFKPYNFSAR	ubiquitination	[1]
315	QGYKYTWKLEEARKN	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 193 193 Phosphoserine (By similarity).
 MOD_RES 311 311 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:EC.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro. 

Interpro

 IPR006195; aa-tRNA-synth_II.
 IPR013196; HTH_11.
 IPR004529; Phe-tRNA-synth_IIc_asu.
 IPR002319; Phenylalanyl-tRNA_Synthase.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF08279; HTH_11
 PF01409; tRNA-synt_2d 

SMART

  

PROSITE

 PS50862; AA_TRNA_LIGASE_II 

PRINTS