| Tag | Content |
|---|
| CPLM ID | CPLM-016904 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysine-specific histone demethylase 1B |
Protein Synonyms/Alias | Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 2 |
Gene Name | Kdm1b |
Gene Synonyms/Alias | Aof1; Lsd2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 655 | PLSEKKMKAINSLGA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. |
Sequence Annotation | DOMAIN 281 379 SWIRM.
ZN_FING 133 193 CW-type.
NP_BIND 389 445 FAD (Potential).
MOD_RES 17 17 Phosphoserine (By similarity).
MOD_RES 253 253 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Chromatin regulator; Complete proteome; Developmental protein; FAD; Flavoprotein; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 826 AA |
Protein Sequence | MAASRGRSKK RSNLELSPDN LPLRSSGRQA KKKAVEIPDE DEDGSSEKKY RKCEKAGCTA 60
AYPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY RSHKDGYDKY SAWKRVWTSN 120
GKTEPSPKAF MADQQLPYWV QCTKPECGKW RQLTKEIQLT PHMARTYRCG MKPNTITKPD 180
TPDHCSFPED LRVLEVSNHW WYPMLIQPPL LKDSVAAPLL SAYYPDCVGM SPSCTSTHRA 240
TVTAATTTTG SASPGEMEPS KAAPSSLVLG MNRYFQPFYQ PNECGKALCV RPDVMELDEL 300
YEFPEYSRDP TMYLALRNLI LALWYTNCKE ALTPQKCIPH IIVRGLVRIR CVQEVERILY 360
FMTRKGLINT GVLTVAAGQH LLPKHYHNKS VLVVGAGPAG LAAARQLHNF GMKVTVLEAK 420
DRIGGRVWDD KSFKGVVVGR GPQIVNGCIN NPVALMCEQL GISMRKLGER CDLIQEGGRI 480
TDPTVDKRMD FHFNALLDVV SEWRKDKTLL QDVPLGEKIE EIYRAFVKES GIQFSELEGQ 540
VLQFHLSNLE YACGSSLHQV SARSWDHNEF FAQFAGDHTL LTPGYSTIIE KLAEGLDIRL 600
KSPVQSIDYT GDEVQVTTTD GMGHSAQKVL VTVPLAILQR GAIQFNPPLS EKKMKAINSL 660
GAGIIEKIAL QFPYRFWDSK VQGADFFGHV PPSASQRGLF AVFYDMDSQQ SVLMSVITGE 720
AVASLRTMDD KQVLQQCMGI LRELFKEQEI PEPTKYFVTR WSTEPWIQMA YSFVKTFGSG 780
EAYDIIAEEI QGTVFFAGEA TNRHFPQTVT GAYLSGVREA SKIAAF 826 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0050660; F:flavin adenine dinucleotide binding; IDA:UniProtKB. GO:0034648; F:histone demethylase activity (H3-dimethyl-K4 specific); IDA:UniProtKB. GO:0034649; F:histone demethylase activity (H3-monomethyl-K4 specific); IDA:UniProtKB. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IDA:UniProtKB. GO:0043046; P:DNA methylation involved in gamete generation; IMP:MGI. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0044030; P:regulation of DNA methylation; IMP:UniProtKB. GO:0006349; P:regulation of gene expression by genetic imprinting; IMP:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PRINTS | |