UniProt Accession

 D6RDE2_MOUSE; D6RDE2 

Genbank Protein ID

 AC116573; AC123060 

Genbank Nucleotide ID

  

Protein Name

 Peptidyl-prolyl cis-trans isomerase 

Protein Synonyms/Alias

  

Gene Name

 Fkbp4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	EGVDISPKQDEGVLK	ubiquitination	[1]
35	KQDEGVLKVIKREGT	acetylation	[2]
74	FDSSLDRKDKFSFDL	ubiquitination	[1]
76	SSLDRKDKFSFDLGK	acetylation	[3]
83	KFSFDLGKGEVIKAW	ubiquitination	[1]
108	EVCHITCKPEYAYGA	acetylation	[2]
222	EHSIVYLKPSYAFGS	ubiquitination	[1]
232	YAFGSVGKERFQIPP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Isomerase; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0035259; F:glucocorticoid receptor binding; IDA:MGI.
 GO:0005525; F:GTP binding; IDA:MGI.
 GO:0031072; F:heat shock protein binding; IDA:MGI.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0051219; F:phosphoprotein binding; IDA:MGI.
 GO:0030521; P:androgen receptor signaling pathway; IMP:MGI.
 GO:0007566; P:embryo implantation; IMP:MGI.
 GO:0046661; P:male sex differentiation; IMP:MGI.
 GO:0030850; P:prostate gland development; IMP:MGI.
 GO:0031503; P:protein complex localization; IDA:MGI.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0006463; P:steroid hormone receptor complex assembly; IDA:MGI. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS