CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039112
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Dst 
Protein Synonyms/Alias
  
Gene Name
 Dst 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1408EKSLDEEKKQHVEKAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5350 AA 
Protein Sequence
DERDKVQKKT FTKWINQHLM KVRKHVNDLY EDLRDGHNLI SLLEVLSGDT LPREKGRMRF 60
HRLQNVQIAL DYLKRRQVKL VNIRNDDITD GNPKLTLGLI WTIILHFQIS DIHVTGESED 120
MSAKERLLLW TQQATEGYAG VRCENFTTCW RDGKLFNAII HKYRPDLIDM NTVAVQSNLA 180
NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE KSVITYVSSL YDAFPKVPEG GEGIGANDVE 240
VKWIEYQNMV NYLIQWIRHH VVTMSERTFP NNPLELKALY NQYLQFKEKE IPPKETEKSK 300
IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK EWGKLIIAML EREKALRPEV ERLDMLQQIA 360
TRVQRDSVSC EDKLMLARNA LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI 420
LLDGKYYQAE QLVQRVAKLR DEILALRNEC SAVYSKGRML TTEQTKLMIS GITQSLNSGF 480
AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS SGMTSRLTPS VTPAYTPGFP SVVAPNFSVG 540
VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD 600
LPSVESHLEN HKNVHRAIEE FESSLKEAKI SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT 660
SRNQERHLDT LHNFVTRATN ELIWLNEKEE SEVAYDWSER NSNVARKKGY HAELMRELEQ 720
KEESIKAVQE IAEQLLLESH PARLTIEAYK AAMQTQWSWI LQLCQCVEQH IQENTAYFEF 780
FNDAKEATDY LRNLKDAIQR KYVCDRSSSI RKLEDLVQES MEKEELLQYR SVVAGLMGRA 840
KTVVQLKPRN PDNPLKTSIP IKAICDYRQI EITIYKDDEC VLANNSHRAK WKVISPTGNE 900
AMVPSVCFTV PPPNKEAVDF ANRIEQQYQS VLTLWHESHV NMKSIVSWHY LVNEIDRIRA 960
SNVASIKTML PGEHQQVLSN LQSRLEDFLE DSQESQIFSG SDITQLEKEV NVCRKYYQEL 1020
LKSAEREEQE ESVYNLYVSE VRNIRLRLES CEDRLIRQIR TPLERDDLHE SMLRITEQEK 1080
LKKELERLKD DLEAITNKCE EFFSQAADSP SVPALRSELS VVLQSMSQIY SMSATYVEKL 1140
KTVNLVLKNT QAAEALVKLY ETKLCEEEAV IADKNNIENL MSTLKQWRSE VDEKREVFHA 1200
LEDELQKAKA ISDEMFKTHK ERDLDFDWHK EKADQLVERW QSVHVQIDNR LRDLEGIGKS 1260
LKHYRDSYHP LDDWIQQIET TQRKIQENQP ENSKALAVQL NQQKMLVSEI EVKQSKMDEC 1320
QKYSEQYSAA VKDYELQTMT YRAMVDSQQK SPMKRRRIQS SADLIIQEFM DLRTRYTALV 1380
TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ HVEKAKELQK WVSNISETLG DGERAGKPHF 1440
SKQQISSKEI SAKKEQFSEA LQNTQIFLAK HGDKLTEEDR SDLEKQVKTL QEGYNLLFSE 1500
SLKQQELQPS GEAKVKPDKV VAERQQEYKE KLQGLCDLLT QTENRLISHQ ETFVIGDGTV 1560
ELKKYQSKQE ELQRDMQGST QALAEIVRNT EIFLKESGDE LSQEDKALIE QKLNEAKVKC 1620
EQLNLKAEQS TKELDKVVTA ALKEETEKVA AARQLEESKT KIENLLNWLS NVEKDSEGSG 1680
RLHTQPLEQN GTHLHEGDGT SEAGEEDEVN GNLLETDAEG HGGMTEGNLN QQYEKVKAQH 1740
EKIVAQHQAV IMATQSAQAL LEKQGHHLSP EEKEKLQANV QELKAHYETV LAECEKKVKL 1800
THSLQEELEK FDADCGEFEH WLQQSEQELE NLEAGADDLS GLTDKLARQK SFSEDVISHK 1860
GDLRYITISG NRVMEAAKSC SKRDGDRIGK DSLETSATHR EVQTKLDQVT DRFRCLYSKC 1920
SVLGNNLKDL VDKYQHYEDA SCGLLSGLQA CEAKASRHLL EPIALDPKNL QRQLEETKAL 1980
QGQISSQQAA VEKLKKTAEV LLDAKGSLLP AKNDIQKTLD DIVGRYDDLS KSVNERNEKL 2040
QITLTRSLSV QDGLDEMLDW MGSVESSLVK QGQVPLNSTA LQDLISKNIM LDQDITGRQS 2100
SINAMNEKVK TFIETTDPST ASSLQAKMKD LSARFSEASQ KHKEKLAKMV ELKSKVEEFE 2160
KLSDKLQTFL ETQSQALTEV DMPGKDVPEL SQHMQESTTK FLEHRKDLEA LHSLLKEISS 2220
HGLPGDKALV FEKTNNLSKK FKELEDTIQE KKEALSSCQE QLSAFHDLAQ SLKTWIKETT 2280
KQVPIVKPSF GTEDLEKSLE ETKKLQEKWS LKTPEIHKAN NSGVSLCNLL SALISPAKAI 2340
AAARSGGVIL NGEGTDTNTQ DFLANKGLTS IKTDMTDISH SYEDLGLLLK DKIVELNTKL 2400
SKLQKAQEES SAMMQWLQKM NKTASRWRQT PTPADSESVK IQVEQNKSFE AELKQNVNKV 2460
QELKDKLAEL LKENPEAPEA PSWKQTMAEM DTKWQELNQL TIDRQQKLEE SSNNLSQFQT 2520
TEAQLKQWLV EKELMVSVLG PLSTDPNMLN TQKQQAQILL QEFDTRKPQY EQLTAAGQGI 2580
LSRPGEDPSL HGIVKEQLAA VTQKWDNLTG QLRDRCDWID QAIVKSTQYQ SLLRSLSGTL 2640
TELDEKLSSS LISGTLPDAV NQQLEAAQKL KQEIEQQTPK IKEAQTLCED LSALVKEEYL 2700
RAELSRQLEG VLKSFKDIEQ KTENHVQHLQ SACASSHQFQ QMSKDFQAWL DAKKEEQRNS 2760
PPISAKLDVL ESLLKAQKDF GKTFTEQSNI YEKTVAEGEN LLSKTQGAEK AALQLQLNTI 2820
KTDWDRFRKQ VKEREEKLKE SLEKALRYRE QVDTLQPWVD KCQHSLESVK LSLDPADTER 2880
SITELKTLQK EMDHHFGTLE LLNNSANSLL SVCEVDKEVV TEGNKSLIQK VNVVTEQLQS 2940
KKVSLENMAQ KFKEFQEVSK DAKRQLQDTK EQLEVYQSLG PQACSNKHLT MLQAQQKSLQ 3000
TLKHQVDSAR RLAQDLVMEA TDPKGTSDVL SQAETLAEEH RGLSQQVDEK CSFLETKLQG 3060
LGHFQNTIRE MFSQFTEFDD ELDSMAPVGR DVETLQKQKA SMQTFLKKLE ALITSNDSAN 3120
RTCKMMLATE ETSPDLIGVK RDLEALSKQC NKLLDRAKTR EEQVSGATEK LEEFHRKLEE 3180
FSTLLQKAEE HEESQGPVGT ETDAINQQLD VFKIFQKEEI EPLQAKQQDV NWLGQGLIQS 3240
AAANTCTQGL EHDLDSINAR WKTLNKKVAQ RTSQLQEALL HCGRFQDALE SLLSWMADTE 3300
ELVANQKPPS AEFKVVKAQI QEQKLLQRLL EDRKSTVEAI KREGEKIAAS AEPADRVKLS 3360
RQLSLLDSRW EMLLSRAEAR NRQLEGISVV AQEFHETLEP LNEWLTAVEK KLANSEPIGT 3420
QAPKLEEQIA QHKALQEDIL LRKQSVDQAL LNGLELLKQT TGDEVLIIQD KLEAIKARYK 3480
DITKLSADVA KTLEHALQLA GQLQSKHKEL CNWLDRVEVE LLSYETQGLK GEAASQVQER 3540
QKELKNEVRN NKALLDSLNE VSSALLELVP WRAREGLEKT VAEDNERYRL VSDTITQKVE 3600
EIDAAILRSQ QFDQAADAEL SWITETQKKL MSLGCIRLEQ DQTSAQLQAQ KAFTMDILRH 3660
KDIIDELVTS GHKIMTTSSE EEKQSMKKKL DKVLKKYDAI CQINSERHLQ LERAQSLVSQ 3720
FWETYEELWP WLMETQQIIS QLPAPALEYE TLRRQQEEHR QLRELIAEHK PHIDKMNKTG 3780
PQLLELSPKE GVHIQEKYVA ADTLYSQIKE DVKKRAVVLD EAISQSTQFH DKIDQILESL 3840
ERIAERLRQP PSISAEVEKI KEQIGENKSV SVDMEKLQPL YETLRQRGEE MIARSEGTEK 3900
DISAKAVQDK LDQMVFIWGS IHTLVEDREA KLLDVMELAE KFWCDHMSLV VTTKDTQDFI 3960
RDLEDPGIDP SVVKQQQEAA EAIREEIDGL QEELDMVITL GSELIAACGE PDKPIVKKSI 4020
DELNSAWDSL NKAWKDRIDR LGEAMQAAVQ YQDGLQAIFD WVDIAGNKLA TMSPIGTDLE 4080
TVKQQIEELK QFKSEAYQQQ IEMERLNHQA ELLLKKVTEE VDKHTVQDPL MELKLIWDSL 4140
DERIVSRQHK LEGALLALGQ FQHALDELLA WLTHTKGLLS EQKPVGGDPK AIEIELAKHH 4200
VLQNDVLAHQ STVEAVNKAG NDLIESSEGE EASNLQYKLR ILNQRWQDIL EKTDQRKQQL 4260
DSALRQAKGF HGEIEDLQQW LTDTERHLLA SKPLGGLPET AREQLNAHME VCTAFAIKEE 4320
TYKNLMLRGQ QMLARCPRSV ETNIDQDITN LKEKWESVKS KLNEKKTKLE EALHLAMEFH 4380
NSLQDFINWL TQAEQTLNVA SRPSLILDTI LFQIDEHKVF ANEVNSHREQ IIELDKTGTH 4440
LKYFSQKQDV VLIKNLLISV QSRWEKVVQR LVERGRSLDE ARKRAKQFHE AWSKLMEWLE 4500
DSEKSLDSEL EIANDPDKIK AQLVQHKEFQ KSLGGKHSVY DTTNRTGRSL KEKTSLADDT 4560
LKLENMLSEL RDKWDTICGK SVERQNKLEE ALLFSGQFTD ALQALIDWLY RVEPQLAEDQ 4620
PVHGDIDLVM NLIDNHKVFQ KELGKRTSSV QALKRSAREL IEGSRDDSSW VRVQMQELST 4680
RWETVCALSI SKQTRLESAL QQAEEFHSVV HTLLEWLAEA EQTLRFHGAL PDDEDALRTL 4740
IEQHKEFMKK LEEKRAELNK ATGMGDALLT ACHPDSITTI KHWITIIQAR FEEVLAWAKQ 4800
HQQRLAGALA GLIAKQELLE NLLAWLQWAE TTLTEKDKEV IPQEIEEVKT LIAEHQTFME 4860
EMTRKQPDVD KVTKTYKRRA ADPPSLQSHI PVLDKGRAGR KRFPASGLYP SGSQTQIETK 4920
NPRANLLVSK WQQVWLLALE RRRKLNDALD RLEELREFAN FDFDIWRKKY MRWMNHKKSR 4980
VMDFFRRIDK DQDGKITRQE FIDGILSSKF PTSRLEMSAV ADIFDRDGDG YIDYYEFVAA 5040
LHPNKDAYKP ITDADKIEDE VTRQVAKCKC AKRFQVEQIG DNKYRFLLLN HFGDSQQLRL 5100
VRILRSTVMV RVGGGWMALD EFLVKNDPCR VHHHGSKMLR SESNSSITAT QPTLAKGRTN 5160
MELREKFILA DGASQGMAAF RPRGRRSRPS SRGASPNRST SASSHACQAA SPQVPAAAST 5220
PKGTPIQGSK LRLPGYLSGK GFHSGEDNAL ITTAASRVRT QFAESRKTPS RPGSRAGSKA 5280
GSRASSRRGS DASDFDISEI QSVCSDVETV PQTHRPAPRA GSRPSTAKPS KIPTPQRKSP 5340
ASKLDKSSKR 5350 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR003108; GAS2_dom.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5
 PF02187; GAS2
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00243; GAS2
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51460; GAR 
PRINTS