CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039221
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Mll1 
Protein Synonyms/Alias
  
Gene Name
 Kmt2a 
Gene Synonyms/Alias
 Mll; Mll1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
133IKKLRAGKLSPLKSKacetylation[1]
985EPLAPPIKPIKPVTRacetylation[1]
2602QIPKRNGKENGTENLacetylation[1]
2814VISDSGEKRVTITEKacetylation[1]
3405RIQLPLDKGSGKKHKacetylation[1]
3409PLDKGSGKKHKVSHLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3826 AA 
Protein Sequence
DEQFLGFGSD EEVRVRSPTR SPSVKASPRK PRGRPRSGSD RNPAILSDPS VFSPLNKSET 60
KSTDKIKKKD SKSIEKKRGR PPTFPGVKIK ITHGKDIAEL TQGSKEDSLK KVKRTPSAMF 120
QQATKIKKLR AGKLSPLKSK FKTGKLQIGR KGVQIVRRRG RPPSTERIKT PSGLLINSEL 180
EKPQKVRKDK EGTPPLTKED KTVVRQSPRR IKPVRIIPSS KRTDATIAKQ LLQRAKKGAQ 240
KKIEKEAAQL QGRKVKTQVK NIRQFIMPVV SAISSRIIKT PRRFIEDEDY DPPIKIARLE 300
STPNSRFSAT SCGSSEKSSA ASQHSSQMSS DSSRSSSPSI DTTSDSQASE EIQALPEERS 360
NTPEVHTPLP ISQSPENESN DRRGRRYSMS ERSFGSRTTK KLPTLQSAPQ QQTSSSPPPP 420
LLTPPPPLQP ASGISDHTPW LMPPTIPLAS PFLPASAAPM QGKRKSILRE PTFRWTSLKH 480
SRSEPQYFSS AKYAKEGLIR KPIFDNFRPP PLTPEDVGFA SGFSASGSAA SARLFSPLHS 540
GTRFDIHKRS PILRAPRFTP SEAHSRIFES VTLPSNRTSS GASSSGVSNR KRKRKVFSPI 600
RSEPRSPSHS MRTRSGRLST SELSPLTPPS SVSSSLSIPV SPLAASALNP TFTFPSHSLT 660
QSGESTEKSQ RARKQTSAPA EPFSSNSPAL FPWFTPGSQT EKGRKKDTAP EELSKDRDAD 720
KSVEKDKSRE RDREREKENK RESRKEKRKK GSDIQSSSAL YPVGRVSKEK VAGEDVGTSS 780
SAKKATGRKK SSSLDSGADI APVTLGDTTA VKAKILIKKG RGNLEKNNLD LGPTAPSLEK 840
EKTLCLSTPS PSTVKHSTSS IGSMLAQADK LPMTDKRVAS LLKKAKAQLC KIEKSKSLKQ 900
TDQPKAQGQE SDSSETSVRG PRIKHVCRRA AVALGRKRAV FPDDMPTLSA LPWEEREKIL 960
SSMGNDDKSS IAGSEDAEPL APPIKPIKPV TRNKAPQEPP VKKGRRSRRC GQCPGCQVPE 1020
DCGVCTNCLD KPKFGGRNIK KQCCKMRKCQ NLQWMPSKAY LQKQTKAVKK KEKKSKATEK 1080
KESKESTVVK SSLESAQKAA PPVREEPAPK KSSSEPPPRK PVEEKTEEGG APPAPAPAPE 1140
PKQASTPASR KSSKQVSQPA AVVPPQPPST ALQKKEAPKA IPSEPKKKQP PPPESGPEQS 1200
KQKKVAPRPS IPVKQKPKDK EKPPPVSKQE NAGTLNILNP LLNGISSKQK IPADGVHRIR 1260
VDFKEDCEAE NVWEMGGLGI LTSVPITPRV VCFLCASSGH VEFVYCQVCC EPFHKFCLEE 1320
NERPLEDQLE NWCCRRCKFC HVCGRQHQAT KQLLECNKCR NSYHPECLGP NYPTKPTKKK 1380
KVWICTKCVR CKSCGSTTPG KGWDAQWSHD FSLCHDCAKL FAKGNFCPLC DKCYDDDDYE 1440
SKMMQCGKCD RWVHSKCEGL SGTEDEMYEI LSNLPESVAY TCVNCTERHP AEWRLALEKE 1500
LQASLKQVLT ALLNSRTTSH LLRYRQAAKP PDLNPETEES IPSRSSPEGP DPPVLTEVSK 1560
QDEQQPLDLE GVKKKMDQGN YVSVLEFSDD IVKIIQAAIN SDGGQPEIKK ANSMVKSFFI 1620
RQMERVFPWF SVKKSRFWEP NKVSNNSGML PNAVLPPSLD HNYAQWQERE ESSHTEQPPL 1680
MKKIIPAPKP KGPGEPDSPT PLHPPTPPIL STDRSREDSP ELHPPPGIDD NRQCALCLMY 1740
GDDSANDAGR LLYIGQNEWT HVNCALWSAE VFEDDDGSLK NVHMAVIRGK QLRCEFCQKP 1800
GATVGCCLTS CTSNYHFMCS RAKNCVFLDD KKVYCQRHRD LIKGEVVPEN GFEVFRRVFV 1860
DFEGISLRRK FLNGLEPESV HVMIGSMTID CLGILNDLSD CEDKLFPIGY QCSRVYWSTT 1920
DARKRCVYTC KIMECRPPVV EPDINSTVEH DDNRTIAHSP SSFIEASCKD SQSTAAILSP 1980
PSPDRPRSQA SSSCYCHVIS KVPRIRTPSY SPTQRSPGCR PLPSAGSPTP TTHEIVTVGD 2040
PLLSSGLRSI GSRRHSTSSL SPLRSKLRIM SPVRSGSVYS RSSVSSVPSL GTATDPESSA 2100
KATDRAGPLN SSANLGHSTP VSSGSQRTVV TGGSKTSHLD GSSSSGVKRS SASDLAPKGS 2160
SLKGEKNRTP GSKSTDGSAH NTAYSGIPKL APQVLNAAPG ELNVSKIGTF AEPSTVPFSK 2220
ETVSYPQLHL RGQRSDRDQH MDSTQSVKPS PNEDGEIKTL KLPGMGHRPS ILHEHVGSSS 2280
RDRRQKGKKS SKETCKEKHS SKSFLEPGQV TTGEEGNLKP EFADEVLTPG FLGQRPCNNV 2340
SSDKTGDKIL PLSGVPKGQS TQVEGSSKEL QAPRKCSVKV TPLKMESENQ SKNTQKESGP 2400
GSPAHMESAC PAEPASASRS PGAGPGVQPS PNNTSSQDPQ SNNYQNLPEQ DRNLMIPDGP 2460
KPQEDGSFKR RYPRRSARAR SNMFFGLTPL YGVRSYGEED IPFYSSSTGK KRGKRSAEGQ 2520
VDGADDLSTS DEDDLYYYNF TRTVISSGGD ERLASHNLFR EEEQCDLPKI SQLDGVDDGT 2580
ESDTSVTATS RKSSQIPKRN GKENGTENLK IDRPEDAGEK EHVIKSAVGH KNEPKLDNCH 2640
SVSRVKAQGQ DSLEAQLSSL ESSRRVHTST PSDKNLLDTY NTELLKSDSD NNNSDDCGNI 2700
LPSDIMDFVL KNTPSMQALG ESPESSSSEL LTLGEGLGLD SNREKDMGLF EVFSQQLPAT 2760
EPVDSSVSSS ISAEEQFELP LELPSDLSVL TTRSPTVPSQ NSSRLAVISD SGEKRVTITE 2820
KSVTSTEGDP ALLSPGVDPA PEGHMTPDHF IQGHMDADHI SSPPCGSVEQ GHGNNQDLTR 2880
NSSTPGLQVP VSPTVPIQNQ KYVPNSTDSP GPSQISNAAV QTTPPHLKPA TEKLIVVNQN 2940
MQPLYVLQTL PNGVTQKIQL TSPVSSTPNV METNTSVLGP MGSGLTLTTG LNPSLPPSQS 3000
LFPPASKGLL SMPHHQHLHS FPAAAQSSFP PNISSPPSGL LIGVQPPPDP QLLGSEANQR 3060
TDLTTTVTTP SSGLKKRPIS RLHTRKNKKL APSSAPSNIA PSDVVSNMTL INFTPSQLSN 3120
HPSLLDLGSL NPSSHRTVPN IIKRSKSGIM YFEQAPLLPP QSVGGTTATG AGSSTISQDT 3180
SHLTSGPVSA LASGSSVLNV VSMQTTTTPT SSTSVPGHVT LANQRLLGTP DIGSISHLLI 3240
KASHQSLGIQ DQPVALPQSS GMFPQLGTSQ TPSAAAMTAA SSICVLPSSQ TAGMTAASPP 3300
REAEEQYKLQ RVNQLLAGKT GTLSLQRDRD PDSAPGTQPS NFTQTAEAPN GVRLEQNKTL 3360
PSAKQASSTS PGSSPSSGQQ SGSSSVPGPT KPKPKVKRIQ LPLDKGSGKK HKVSHLRTSS 3420
EAHIPHREAN PAPQPSVKRT PRADREQQEA AGVEQPSQKE CGQPAGPATA LPEIQATQNP 3480
ANEQENAEPK AVEEEESSFS SPLMLWLQQE QKRKESITER KPKKGLVFEI SSDDGFQICA 3540
ESIEDAWKSL TDKVQEARSN ARLKQLSFAG VNGLRMLGIL HDAVVFLIEQ LSGAKHCRNY 3600
KFRFHKPEEA NEPPLNPHGS ARAEVHLRKS AFDMFNFLAS KHRQPPEYNP NDEEEEEVQL 3660
KSARRATSMD LPMPMRFRHL KKTSKEAVGV YRSPIHGRGL FCKRNIDAGE MVIEYAGNVI 3720
RSIQTDKREK YYDSKGIGCY MFRIDDSEVV DATMHGNAAR FINHSCEPNC YSRVINIDGQ 3780
KHIVIFAMRK IYRGEELTYD YKFPIEDASN KLPCNCGAKK CRKFLN 3826 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; IEA:InterPro.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0006306; P:DNA methylation; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Compara. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR001487; Bromodomain.
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR016569; MeTrfase_trithorax.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR002857; Znf_CXXC.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00628; PHD
 PF00856; SET
 PF02008; zf-CXXC 
SMART
 SM00384; AT_hook
 SM00297; BROMO
 SM00542; FYRC
 SM00541; FYRN
 SM00249; PHD
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS50014; BROMODOMAIN_2
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET
 PS51058; ZF_CXXC
 PS50016; ZF_PHD_2 
PRINTS