CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036581
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 2 
Protein Synonyms/Alias
  
Gene Name
 DOCK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51WYRGYLIKHKMLQGIubiquitination[1]
61MLQGIFPKSFIHIKEubiquitination[2]
67PKSFIHIKEVTVEKRubiquitination[1, 3]
110KQLYVASKKERFLQVubiquitination[1]
111QLYVASKKERFLQVQubiquitination[1]
138LLSGTLPKDELKELKubiquitination[1]
145KDELKELKQKVTSKIubiquitination[1]
151LKQKVTSKIDYGNKIubiquitination[1, 3]
199DKITERIKEEMSKDQubiquitination[1, 3, 4]
204RIKEEMSKDQPDYAMubiquitination[1, 3]
268WGSRGFPKEIEMLNNubiquitination[1, 2, 3]
286VFTDLGNKDLNRDKIubiquitination[1]
304CQIVRVGKMDLKDTGubiquitination[1]
308RVGKMDLKDTGAKKCubiquitination[1]
335MDITDIIKGKAESDEubiquitination[1]
337ITDIIKGKAESDEEKubiquitination[1]
371LGKVIASKGDSGGQGubiquitination[1, 2, 3, 4]
395GDIIQIRKDYPHLVDubiquitination[1, 3]
410RTTVVARKLGFPEIIubiquitination[1, 2, 3]
437LLQGDFDKYNKTTQRubiquitination[1]
440GDFDKYNKTTQRNVEubiquitination[1, 3]
471ICVGAGDKPMNEYRSubiquitination[1]
485SVVYYQVKQPRWMETubiquitination[1, 3]
494PRWMETVKVAVPIEDubiquitination[1, 4]
525ESKDKGEKNFAMSYVubiquitination[1]
533NFAMSYVKLMKEDGTubiquitination[1, 3]
558VLKGDSKKMEDASAYubiquitination[1]
578YRHHVENKGATLSRSubiquitination[1, 5]
610STLVCSTKLTQNVGLubiquitination[5]
622VGLLGLLKWRMKPQLubiquitination[1, 2, 3, 4, 5]
626GLLKWRMKPQLLQENubiquitination[1, 3]
835PVKLQKQKVQSMNEIubiquitination[1]
849IVQSNLFKKQECRDIubiquitination[1]
850VQSNLFKKQECRDILubiquitination[1]
863ILLPVITKELKELLEubiquitination[1, 2, 3]
866PVITKELKELLEQKDubiquitination[1, 3]
872LKELLEQKDDMQHQVubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1031 AA 
Protein Sequence
MAPWRKADKE RHGVAIYNFQ GSGAPQLSLQ IGDVVRIQET CGDWYRGYLI KHKMLQGIFP 60
KSFIHIKEVT VEKRRNTENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM 120
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDNTSV 180
ISLFHAHEEA TDKITERIKE EMSKDQPDYA MYSRISSSPT HSLYVFVRNF VCRIGEDAEL 240
FMSLYDPNKQ TVISENYLVR WGSRGFPKEI EMLNNLKVVF TDLGNKDLNR DKIYLICQIV 300
RVGKMDLKDT GAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVTAENDFL 360
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG 420
DVRNDIYITL LQGDFDKYNK TTQRNVEVIM CVCAEDGKTL PNAICVGAGD KPMNEYRSVV 480
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT 540
TLHDGFHDLV VLKGDSKKME DASAYLTLPS YRHHVENKGA TLSRSSSSVG GLSVSSRDVF 600
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM 660
MEHSQSDEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY 720
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL 780
MKSQYKTTIL LQVAALKYIP SVLHDVEMVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN 840
EIVQSNLFKK QECRDILLPV ITKELKELLE QKDDMQHQVL ERKYCVELLN SILEVLSYQD 900
AAFTYHHIQE IMVQLLRTVN RTVITMGRDH ILISHFVACM TAILNQMGDQ HYSFYIETFQ 960
TSSELVDFLM ETFIMFKDLI GKNVYPGDWM AMSMVQNRVF LRAINKFAET MNQKFLEHTN 1020
FEFQGFSRTG M 1031 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR026791; DOCK.
 IPR026799; DOCK_A.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF14429; DOCK-C2
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS51650; DHR_1
 PS50002; SH3 
PRINTS