CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008739
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 2/3 complex subunit 2 
Protein Synonyms/Alias
 Arp2/3 complex 34 kDa subunit; p34-ARC 
Gene Name
 ARC35 
Gene Synonyms/Alias
 YNR035C; N3296 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
245KRLYQPPKVAEQSRRubiquitination[1]
313IKVLNRAKVDEDDENubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). 
Sequence Annotation
 MOD_RES 155 155 Phosphothreonine.
 MOD_RES 324 324 Phosphoserine.  
Keyword
 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MLHLQPQNLL IQKTLNEAIE ALRKGSPLTM DRIVSDFDYT TYHISNTAED KSILLLSVKT 60
KAWVSVSECQ LDGSLTLLKF LADHYSSLGG VTIPSEVEPG YDYTLQITLA ELVQESILQL 120
SVLKTIILSF PFELAISKFI ELSQQQPAPV EAEITGGEVA ANGDNTLFTI KYRDEENIFI 180
KPSNDRVTII FETIFQDETD KIFGKVFLQE FVDARKRNRQ IQSAPQVLYS HEPPLELKRL 240
YQPPKVAEQS RRFITFVLFP RHFQTKELQF HSICQLTLFR NYFHYHIKCS KAYMHSRMRF 300
RVDSFIKVLN RAKVDEDDEN DELSAEGRQQ ARRTFTGRKI VY 342 
Gene Ontology
 GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
 GO:0005885; C:Arp2/3 protein complex; IDA:SGD.
 GO:0005829; C:cytosol; IPI:SGD.
 GO:0005198; F:structural molecule activity; IMP:SGD.
 GO:0030036; P:actin cytoskeleton organization; IPI:SGD.
 GO:0000226; P:microtubule cytoskeleton organization; IPI:SGD.
 GO:0000001; P:mitochondrion inheritance; TAS:SGD.
 GO:0006898; P:receptor-mediated endocytosis; IMP:SGD.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 
Interpro
 IPR007188; P34-arc. 
Pfam
 PF04045; P34-Arc 
SMART
  
PROSITE
  
PRINTS