CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011962
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Active breakpoint cluster region-related protein 
Protein Synonyms/Alias
  
Gene Name
 ABR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
87APGVEAGKGLEMRKLubiquitination[1]
192KAFVDNYKVALETAEubiquitination[1]
200VALETAEKCSQSNNQubiquitination[1]
210QSNNQFQKISEELKVubiquitination[1]
216QKISEELKVKGPKDSubiquitination[1]
238TMEALLYKPIDRVTRubiquitination[1]
383ELEDMKMKISALKSEubiquitination[1]
388KMKISALKSEIQKEKubiquitination[1]
581YDKTKVNKDNNEIVDubiquitination[1]
593IVDKIMGKGQIQLDPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. 
Sequence Annotation
 DOMAIN 91 284 DH.
 DOMAIN 301 459 PH.
 DOMAIN 463 595 C2.
 DOMAIN 647 845 Rho-GAP.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Guanine-nucleotide releasing factor; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MEPLSHRGLP RLSWIDTLYS NFSYGTDEYD GEGNEEQKGP PEGSETMPYI DESPTMSPQL 60
SARSQGGGDG VSPTPPEGLA PGVEAGKGLE MRKLVLSGFL ASEEIYINQL EALLLPMKPL 120
KATATTSQPV LTIQQIETIF YKIQDIYEIH KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ 180
LGVYKAFVDN YKVALETAEK CSQSNNQFQK ISEELKVKGP KDSKDSHTSV TMEALLYKPI 240
DRVTRSTLVL HDLLKHTPVD HPDYPLLQDA LRISQNFLSS INEDIDPRRT AVTTPKGETR 300
QLVKDGFLVE VSESSRKLRH VFLFTDVLLC AKLKKTSAGK HQQYDCKWYI PLADLVFPSP 360
EESEASPQVH PFPDHELEDM KMKISALKSE IQKEKANKGQ SRAIERLKKK MFENEFLLLL 420
NSPTIPFRIH NRNGKSYLFL LSSDYERSEW REAIQKLQKK DLQAFVLSSV ELQVLTGSCF 480
KLRTVHNIPV TSNKDDDESP GLYGFLHVIV HSAKGFKQSA NLYCTLEVDS FGYFVSKAKT 540
RVFRDTAEPK WDEEFEIELE GSQSLRILCY EKCYDKTKVN KDNNEIVDKI MGKGQIQLDP 600
QTVETKNWHT DVIEMNGIKV EFSMKFTSRD MSLKRTPSKK QTGVFGVKIS VVTKRERSKV 660
PYIVRQCVEE VEKRGIEEVG IYRISGVATD IQALKAVFDA NNKDILLMLS DMDINAIAGT 720
LKLYFRELPE PLLTDRLYPA FMEGIALSDP AAKENCMMHL LRSLPDPNLI TFLFLLEHLK 780
RVAEKEPINK MSLHNLATVF GPTLLRPSEV ESKAHLTSAA DIWSHDVMAQ VQVLLYYLQH 840
PPISFAELKR NTLYFSTDV 859 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005096; F:GTPase activator activity; TAS:ProtInc.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030675; F:Rac GTPase activator activity; IEA:Compara.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0043314; P:negative regulation of neutrophil degranulation; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00168; C2
 PF00169; PH
 PF00620; RhoGAP
 PF00621; RhoGEF 
SMART
 SM00239; C2
 SM00233; PH
 SM00324; RhoGAP
 SM00325; RhoGEF 
PROSITE
 PS50004; C2
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS