CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Central kinetochore subunit MCM21 
Protein Synonyms/Alias
 Chromosome transmission fidelity protein 5; Minichromosome maintenance protein 21 
Gene Name
 MCM21 
Gene Synonyms/Alias
 CTF5; YDR318W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
229VLLKKRIKSNSWFLFubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle- microtubule attachments and proper chromosome segregation. 
Sequence Annotation
 MOD_RES 88 88 Phosphothreonine.  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Kinetochore; Meiosis; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 368 AA 
Protein Sequence
MSRIDDLQQD IESLLSEINS LEESREKLKA KIKDKRKNEE SANPIVQEFE DLFDQFPQLN 60
NFLFNEHPEL EETDDKDISR AQADIPATPI PYEPKKRAKL ENEEILPEQE WVLKTQPMVQ 120
HQMFDPGVAD LLDTDILTSP SKRKRKLKID DISTSDRSEL EDYIVLENVY RMFGITFFPL 180
VDPIDLKIKD ASGEIFVDRE MLGIRLEVFS ERTSQFEKPH YVLLKKRIKS NSWFLFKHTI 240
PSFIDVQGIF DDTNGGLVIS HDDAYLFAKR VFLQLVEVQK RRQIFKDLEA KKIIHDLDLD 300
LESSMVSFFV KDIKVELFVK QNEIVSCSIL DDIHDFSQNN KSKWEIALLG SLDDLELKLN 360
HSFATIFK 368 
Gene Ontology
 GO:0000817; C:COMA complex; IDA:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034087; P:establishment of mitotic sister chromatid cohesion; IMP:SGD.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW. 
Interpro
 IPR018464; Centromere_CenpO. 
Pfam
 PF09496; CENP-O 
SMART
  
PROSITE
  
PRINTS