CPLM-009509

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-009509

UniProt Accession

ERR3_HUMAN; P62508; A8K4I0; A8K6I2; B3KY84; E9PGB7; F8W8J3; O75454; O96021; Q68DA0; Q6P274; Q6PK28; Q6TS38; Q9R1F3; Q9UNJ4

Genbank Protein ID

AF094518; AB020639; AF058291; AY388456; AY388457; AY388458; AY388459; AY388460; AY388461; AK131193; AK290945; AK291028; AK291647; CR749497; AY528719; AL445650; AL512650; AC096635; AL445650; AC096635; AL512650; AL512650; AC096635; AL445650; AL512650; AC096635; AL445650; AC096634; AL391216; AL512626; AL513312; AL603752; CH471100; BC008218; BC064700; AF117255

Genbank Nucleotide ID

AAC99410.1; BAA74855.2; AAC39899.1; AAQ93376.1; AAQ93377.1; AAQ93378.1; AAQ93379.1; AAQ93380.1; AAQ93381.1; BAG54746.1; BAF83634.1; BAF83717.1; BAF84336.1; CAH18320.1; AAS00098.1; CAH70618.1; CAH70618.1; CAH70618.1; CAH70619.1; CAH70619.1; CAH70619.1; CAH71594.1; CAH71594.1; CAH71594.1; CAH71595.1; CAH71595.1; CAH71595.1; EAW93335.1; AAH08218.1; AAH64700.1; AAD48370.1

Protein Name

Estrogen-related receptor gamma

Protein Synonyms/Alias

ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3

Gene Name

ESRRG

Gene Synonyms/Alias

ERR3; ERRG2; KIAA0832; NR3B3

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
40	SSCSSFIKTEPSSPA	sumoylation	[1]

Reference

[1] Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.
Tremblay AM, Wilson BJ, Yang XJ, Giguère V.
Mol Endocrinol. 2008 Mar;22(3):570-84. [PMID: 18063693]

Functional Description

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).

Sequence Annotation

DNA_BIND 125 200 Nuclear receptor.
ZN_FING 128 148 NR C4-type.
ZN_FING 164 188 NR C4-type.
MOD_RES 45 45 Phosphoserine (Probable).
CROSSLNK 40 40 Glycyl lysine isopeptide (Lys-Gly)

Keyword

3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

458 AA

Protein Sequence

MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT DSVNHHSPGG 60
SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML 120
NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC 180
QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH 240
LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 300
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK 360
LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT 420
LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF LEMLEAKV 458

Gene Ontology

GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0050682; F:AF-2 domain binding; ISS:UniProtKB.
GO:0003708; F:retinoic acid receptor activity; IEA:InterPro.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO:0005496; F:steroid binding; IEA:InterPro.
GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.

Interpro

IPR008946; Nucl_hormone_rcpt_ligand-bd.
IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
IPR027289; Oest-rel_rcp.
IPR024178; Oest_rcpt/oest-rel_rcp.
IPR003078; Retinoic_acid_rcpt.
IPR001723; Str_hrmn_rcpt.
IPR001628; Znf_hrmn_rcpt.
IPR013088; Znf_NHR/GATA.

Pfam

PF00104; Hormone_recep
PF00105; zf-C4

SMART

SM00430; HOLI
SM00399; ZnF_C4

PROSITE

PS00031; NUCLEAR_REC_DBD_1
PS51030; NUCLEAR_REC_DBD_2

PRINTS

PR01292; RETNOICACIDR.
PR00398; STRDHORMONER.
PR00047; STROIDFINGER.