UniProt Accession

 TNNI2_HUMAN; P48788; A6NIV8; A6NJU5 

Genbank Protein ID

 L21715; AJ245761; AC051649; BC032148; BI833431 

Genbank Nucleotide ID

 AAA19813.1; CAB59981.1; AAH32148.1 

Protein Name

 Troponin I, fast skeletal muscle 

Protein Synonyms/Alias

 Troponin I, fast-twitch isoform 

Gene Name

 TNNI2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
124	MSADAMLKALLGSKH	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 REGION 2 48 Involved in binding TNC.
 REGION 97 117 Involved in binding TNC and actin.
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Complete proteome; Disease mutation; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005861; C:troponin complex; IDA:UniProtKB.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0003009; P:skeletal muscle contraction; IDA:UniProtKB. 

Interpro

 IPR001978; Troponin. 

Pfam

 PF00992; Troponin 

SMART

  

PROSITE

  

PRINTS