CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock transcription factor, X-linked 
Protein Synonyms/Alias
  
Gene Name
 HSFX1; HSFX2 
Gene Synonyms/Alias
 LW-1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
215MKRRVGVKSAPRHQEsumoylation[1]
Reference
 [1] In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
 Blomster HA, Imanishi SY, Siimes J, Kastu J, Morrice NA, Eriksson JE, Sistonen L.
 J Biol Chem. 2010 Jun 18;285(25):19324-9. [PMID: 20388717
Functional Description
  
Sequence Annotation
 DNA_BIND 98 282 By similarity.
 CROSSLNK 215 215 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MEDKRSLSMA RCEERNSRGQ DHGLERVPFP PQLQSETYLH PADPSPAWDD PGSTGSPNLR 60
LLTEEIAFQP LAEEASFRRP HPDGDVPPQG EDNLLSLPFP QKLWRLVSSN QFSSIWWDDS 120
GACRVINQKL FEKEILKRDV AHKVFATTSI KSFFRQLNLY GFRKRRQCTF RTFTRIFSAK 180
RLVSILNKLE FYCHPYFQRD SPHLLVRMKR RVGVKSAPRH QEEDKPEAAG SCLAPADTEQ 240
QDHTSPNEND QVTPQHREPA GPNTQIRSGS APPATPVMVP DSAVASDNSP VTQPAGEWSE 300
GSQAHVTPVA AVPGPAALPF LYVPGSPTQM NSYGPVVALP TASRSTLAMD TTGLPAPGML 360
PFCHLWVPVT LVAAGAAQPA ASMVMFPHLP ALHHHCPHSH RTSQYMPASD GPQAYPDYAD 420
QST 423 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000232; HSF_DNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00447; HSF_DNA-bind 
SMART
 SM00415; HSF 
PROSITE
 PS00434; HSF_DOMAIN 
PRINTS