CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008258
UniProt Accession
Genbank Protein ID
 U18762 
Genbank Nucleotide ID
Protein Name
 Retinol dehydrogenase 3 
Protein Synonyms/Alias
 Retinol dehydrogenase type I; RODH I 
Gene Name
 Rdh3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
210IIEPGGFKTNVTNMEacetylation[1]
225RLSDNLKKLWDQTTEacetylation[1]
241VKEIYGEKFQDSYMKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD. 
Sequence Annotation
 NP_BIND 33 57 NADP (By similarity).
 ACT_SITE 176 176 Proton acceptor (By similarity).
 BINDING 164 164 Substrate (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Microsome; NAD; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 317 AA 
Protein Sequence
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD RRGMRVLAAC 60
LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER VGNRGLWGLV NNAGISVPVG 120
PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP LVRKARGRVV NIASTMGRMS LVGGGYCISK 180
YGVEAFSDSL RRELTYFGVK VAIIEPGGFK TNVTNMERLS DNLKKLWDQT TEEVKEIYGE 240
KFQDSYMKAM ESLVNTCSGD LSLVTDCMEH ALTSCHPRTR YSPGWDAKFF YLPMSYLPTF 300
LSDAVIHWGS VKPARAL 317 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0004745; F:retinol dehydrogenase activity; IEA:EC.
 GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.