CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NLR family member X1 
Protein Synonyms/Alias
  
Gene Name
 Nlrx1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
299AIGRIPSKYVGRYGEacetylation[1]
657LENAQAIKKKLGKMGacetylation[1]
962LRVESEVKTLLEQLGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Participates in antiviral signaling (By similarity). 
Sequence Annotation
 DOMAIN 158 481 NACHT.
 REPEAT 693 716 LRR 1.
 REPEAT 722 745 LRR 2.
 REPEAT 747 775 LRR 3.
 REPEAT 776 799 LRR 4.
 REPEAT 809 832 LRR 5.
 REPEAT 833 855 LRR 6.
 REPEAT 860 883 LRR 7.
 NP_BIND 164 171 ATP (Potential).
 REGION 73 554 Required for interaction with MAVS (By
 REGION 554 972 Required for the repression of MAVS-  
Keyword
 ATP-binding; Complete proteome; Host-virus interaction; Immunity; Innate immunity; Leucine-rich repeat; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Repeat; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 973 AA 
Protein Sequence
MRWGCHLPRT SWGSGLGRTV PLPDELRIQS SWPFKGVHHP LRPPRAFIRH HGNSADSAPP 60
PGRHGQLFRS ISATEAIQRH RRNLTEWFSR LPREERQFGP TFALDTVHVD PVIRESTPDD 120
LLRPSTELAT GHQRTQAELP PLALSQLFDP DACGRRVQTV VLYGTVGTGK STLVRKMVLD 180
WCYGRLPAFE LLIPFSCEDL SSLGSTPASL CQLVTQRYTP LKEVLPLMNA AGSRLLFVLH 240
GLERLNLDFR LAGTGLCSDP EEPGAPAAIM VNLLRKYMLP EASILVTTRP SAIGRIPSKY 300
VGRYGEICGF SDTNLQKLYF QLRLNQPDCG YGAGGTGVSV TPAQRDNLIQ MLSRNLEGHH 360
QIAAACFLPS YCWLVCATLH FLHAPTSAGQ TLTSIYTSFL RLNFNGETLD STDPSNLSLM 420
SYAARTMGKL AYEGVSSRKT YFSEEDVRGC LEAGIKTEEE FQLLQIFRRD ALRFFLAPCV 480
EPGHLGTFVF TVPAMQEYLA ALYIVLGLRK TALQRVGKEV FEFVGRVGED VSLVLGIVAK 540
LLPLRILPLL FNLLKVVPRV FGRMVSKSRE AVAQAMVLEM FREEDYYNDD VLDQMGASIL 600
GVEGPRRHPD EPPEDEVFEL FPMFMSGLLS AHNRAVLAQL GCPIKNLDAL ENAQAIKKKL 660
GKMGRQVLPP SELLDHLFFH YEFQNQRFSA EVLGSLRQLN LAGVRMTPLK CTVVASVLGS 720
GRHPLDEVNL ASCQLDPAGL HTLMPVLLRA RKLGLQLNNL GPEACRDLRD LLLHDQCQIT 780
TLRLSNNPLT AAGVGVLMDG LAGNTSVTHL SLLHTDLGDE GLELLAAQLD RNKQLQELNV 840
AYNGAGDTVA LALAKAARKH PSLELLHLYF NELSSEGRQV LRDLGGSGEG GARVVASLTE 900
GTAVSEYWSV ILSEVQRNLN SWDPVRVQRH LKLLLRDLED SRGATLNPWR KAQLLRVESE 960
VKTLLEQLGG SGH 973 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR007111; NACHT_NTPase. 
Pfam
  
SMART
  
PROSITE
 PS50837; NACHT 
PRINTS