CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Aspartyl/asparaginyl beta-hydroxylase 
Protein Synonyms/Alias
  
Gene Name
 Asph 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
620KTCALLEKFSETTGCacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 725 AA 
Protein Sequence
MAPRKNAKGG GGNSSSSGSG SGSGSGSPST GSSGSSSSPG ARREAKHGGH KNGRRGGISG 60
GSFFTWFMVI ALLGVWTSVA VVWFDLVDYE EVLGKLGVYD ADGDGDFDVD DAKVLLGLKE 120
RSPSERTFPP EEEAETHAEL EEQAPEGADI QNVEDEVKEQ IQSLLQESVH TDHDLEADGL 180
AGEPQPEVED FLTVTDSDDR FEDLEPGTVH EEIEDTYHVE DTASQNHPND MEEMTNEQEN 240
SEEVRHQDYD EPVYEPSEHE GVAISDNTID DSSIISEEIN VASVEEQQDT PPVKKKKPKL 300
LNKFDKTIKA ELDAAEKLRK RGKIEEAVNA FEELVRKYPQ SPRARYGKAQ CEDDLAEKQR 360
SNEVLRRAIE TYQEAADLPD APTDLVKLSL KRRSERQQFL GHMRGSLLTL QRLVQLFPSD 420
TTLKNDLGVG YLLLGDNDSA KKVYEEVLNV TPNDGFAKVH YGFILKAQNK ISESIPYLKE 480
GIESGDPGTD DGRFYFHLGD AMQRVGNKEA YKWYELGHKR GHFASVWQRS LYNVNGLKAQ 540
PWWTPRETGY TELVKSLERN WKLIRDEGLM VMDKAKGLFL PEDENLREKG DWSQFTLWQQ 600
GRKNENACKG APKTCALLEK FSETTGCRRG QIKYSIMHPG THVWPHTGPT NCRLRMHLGL 660
VIPKEGCKIR CANETRTWEE GKVLIFDDSF EHEVWQDASS FRLIFIVDVW HPELTPQQRR 720
SLPAI 725 
Gene Ontology
 GO:0016021; C:integral to membrane; ISS:MGI.
 GO:0004597; F:peptide-aspartate beta-dioxygenase activity; ISS:MGI.
 GO:0060325; P:face morphogenesis; IMP:MGI.
 GO:0035108; P:limb morphogenesis; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0007389; P:pattern specification process; IMP:MGI.
 GO:0042264; P:peptidyl-aspartic acid hydroxylation; IDA:MGI. 
Interpro
 IPR007943; Asp-B-hydro/Triadin_dom.
 IPR007803; Asp_Arg_b-Hydrxlase.
 IPR027443; IPNS-like.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF05279; Asp-B-Hydro_N
 PF05118; Asp_Arg_Hydrox
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS