CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heat shock protein HSP 90-alpha 
Protein Synonyms/Alias
  
Gene Name
 Hsp90aa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
112NNLGTIAKSGTKAFMacetylation[1, 2]
112NNLGTIAKSGTKAFMsuccinylation[2]
112NNLGTIAKSGTKAFMubiquitination[3]
185EPMGRGTKVILHLKEubiquitination[3]
191TKVILHLKEDQTEYLacetylation[1]
191TKVILHLKEDQTEYLubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 201 AA 
Protein Sequence
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR 60
YESLTDPSKL DSGKELHINL IPSKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME 120
ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM 180
GRGTKVILHL KEDQTEYLEE R 201 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0002135; F:CTP binding; IEA:Compara.
 GO:0032564; F:dATP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0002134; F:UTP binding; IEA:Compara.
 GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0060452; P:positive regulation of cardiac muscle contraction; IEA:Compara.
 GO:0045793; P:positive regulation of cell size; IEA:Compara.
 GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0045040; P:protein import into mitochondrial outer membrane; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N. 
Pfam
 PF02518; HATPase_c 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00298; HSP90 
PRINTS
 PR00775; HEATSHOCK90.