UniProt Accession

 DHPR_HUMAN; P09417; A8K158; Q53F52; Q9H3M5 

Genbank Protein ID

 X04882; M16447; AJ006239; AJ006240; AJ006241; AJ006242; AJ006243; AJ006244; AJ006245; AB053170; AK223437; AK289773; CH471069; BC000576 

Genbank Nucleotide ID

 CAA28571.1; AAA52305.1; CAA06930.1; CAA06930.1; CAA06930.1; CAA06930.1; CAA06930.1; CAA06930.1; CAA06930.1; BAB20429.1; BAD97157.1; BAF82462.1; EAW92777.1; AAH00576.1 

Protein Name

 Dihydropteridine reductase 

Protein Synonyms/Alias

 HDHPR; Quinoid dihydropteridine reductase 

Gene Name

 QDPR 

Gene Synonyms/Alias

 DHPR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
138	LLTLAGAKAALDGTP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. 

Sequence Annotation

 NP_BIND 14 38 NADP.
 ACT_SITE 150 150 Proton acceptor.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; NADP; Oxidoreductase; Phenylketonuria; Polymorphism; Reference proteome; Tetrahydrobiopterin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004155; F:6,7-dihydropteridine reductase activity; EXP:Reactome.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0070404; F:NADH binding; IEA:Compara.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0051066; P:dihydrobiopterin metabolic process; TAS:ProtInc.
 GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0010044; P:response to aluminum ion; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0010288; P:response to lead ion; IEA:Compara.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS